About: Mannose-Binding Lectin and Susceptibility to Schistosomiasis

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About: Mannose-Binding Lectin and Susceptibility to Schistosomiasis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mannose-Binding Lectin and Susceptibility to Schistosomiasis
Creator	Kremsner, Peter Van Tong, Hoang Velavan, Thirumalaisamy Adeyeba, Adegboyega Akindele, Akeem Antony, Justin Engleitner, Thomas Ojurongbe, Olusola Ouf, Eman Sina-Agbaje, Olawumi
source	Medline; PMC
abstract	Background. Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis. Methods. We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium–infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis. Results. MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The −550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes −550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03). Conclusions. In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.
has issue date	2013-06-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jit081
bibo:pmid	23448728
has license	no-cc
sha1sum (hex)	f7edc70b28157bb0ad0fa543b69cb1a0b1231020
schema:url	https://doi.org/10.1093/infdis/jit081
resource representing a document's title	Mannose-Binding Lectin and Susceptibility to Schistosomiasis
has PubMed Central identifier	PMC7107301
has PubMed identifier	23448728
schema:publication	J Infect Dis
resource representing a document's body	covid:f7edc70b28157bb0ad0fa543b69cb1a0b1231020#body_text
is schema:about of	named entity 'Human' named entity 'Schistosomiasis' named entity 'Lectin' named entity 'LECTIN' named entity 'HUMAN' named entity 'ASSOCIATED WITH' named entity 'FCN2' named entity 'MBL2' named entity 'SCHISTOSOMIASIS' named entity 'ACTIVATE' named entity 'SPECIFIC' named entity 'FICOLIN 2' named entity 'SERUM' named entity 'PROTECTIVE FACTORS' named entity 'MANNOSE-BINDING LECTIN' named entity 'PATTERNS' named entity 'MOLECULAR' named entity 'ESTABLISHED' named entity 'LEVELS' named entity 'SIMILAR' named entity 'OUR' named entity 'BACKGROUND' named entity 'SCHISTOSOMIASIS' named entity 'SUSCEPTIBILITY' named entity 'CERTAIN' named entity 'STUDY' named entity 'PATHOGEN' named entity 'BIND' named entity 'INFECTIOUS DISEASES' named entity 'PUBLISHED' named entity 'PROMOTER' named entity 'RECENTLY' named entity 'CASCADE' named entity 'COMPLEMENT' named entity 'VARIANTS' named entity 'ASSOCIATED' named entity 'MANNOSE-BINDING LECTIN' covid:arg/f7edc70b28157bb0ad0fa543b69cb1a0b1231020 named entity 'ficolin' named entity 'mannose-binding lectin' named entity 'Our' named entity 'similar manner' named entity 'serum levels' named entity 'ficolin' named entity 'complement' named entity 'FCN2' named entity 'Thermal cycler' named entity 'malaria' named entity 'schistosome' named entity 'S. haematobium' named entity 'MBL2' named entity 'MBL' named entity 'serum' named entity 'allele' named entity 'Schistosoma' named entity 'pathogen' named entity 'control group' named entity 'immune response' named entity 'MBL2' named entity 'exon' named entity 'schistosome' named entity 'pathogens' named entity 'MBL' named entity 'protein' named entity '5′ untranslated region' named entity 'Ghana' named entity 'SNPs' named entity 'parasite' named entity 'heterozygous' named entity 'parasitological' named entity 'Cryptosporidium' named entity 'infection'

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