About: Lipid peroxidation in Gram-negative bacteremia modulates the risk for septic shock and infections by resistant Klebsiella pneumoniae

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About: Lipid peroxidation in Gram-negative bacteremia modulates the risk for septic shock and infections by resistant Klebsiella pneumoniae Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Lipid peroxidation in Gram-negative bacteremia modulates the risk for septic shock and infections by resistant Klebsiella pneumoniae
Creator	Giamarellos-Bourboulis, E Adamis, G Christodoulou, S Chrysanthakopoulou, & Gkizeli, & Karampela, I Karlis, & Kyriazopoulou, E Safarika, & Veliki, &
source	PMC
abstract	Controversies in outcomes with the parenteral administration of antioxidants as adjuvant therapies led to the measurement of malondialdehyde (MDA), a product of lipid peroxidation, in serum collected from 120 patients with primary Gram-negative bacteremia during the first 24 h from sepsis onset. MDA was measured by the thiobarbiturate assay, followed by high-performance liquid chromatography (HPLC) analysis. After receiver operator characteristic (ROC) curve analysis, patients were divided into those with high levels of MDA and low levels of MDA. The primary endpoint was the association of the level of MDA with septic shock. The level of MDA as an index of neutrophil function and associations with outcome and with infections by carbapenem-resistant Klebsiella pneumoniae were the secondary endpoints. In total, 63 patients had high and 57 had low MDA levels; 27% and 49.1%, respectively, had septic shock (p = 0.015). The rate of the concentration of MDA to the total neutrophil count was used as an expression of neutrophil function; this was lower among patients with septic shock. The odds ratio (OR) for death among patients without septic shock and low level of MDA was 4.00; this was 0.48 for patients with septic shock (p = 0.020 between the two ORs). The OR for resistance to carbapenems among patients with bacteremia by K. pneumoniae and low level of MDA was 7.50 (p = 0.011 compared to patients with bacteremia by other pathogens). Low level of circulating MDA is associated with susceptibility to septic shock and infections by carbapenem-resistant K. pneumoniae.
has issue date	2017-06-21(xsd:dateTime)
bibo:doi	10.1007/s10096-017-3041-5
bibo:pmid	28639164
has license	no-cc
sha1sum (hex)	f8040dfc7d16650a47260dca344dbb97ff2c393a
schema:url	https://doi.org/10.1007/s10096-017-3041-5
resource representing a document's title	Lipid peroxidation in Gram-negative bacteremia modulates the risk for septic shock and infections by resistant Klebsiella pneumoniae
has PubMed Central identifier	PMC7101849
has PubMed identifier	28639164
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:f8040dfc7d16650a47260dca344dbb97ff2c393a#body_text
is schema:about of	named entity 'total' named entity 'patients' named entity 'Lipid peroxidation' named entity '120' named entity 'ANALYSIS' named entity 'SUSCEPTIBILITY' named entity 'CARBAPENEM-RESISTANT KLEBSIELLA' named entity 'ASSOCIATION' named entity 'COLLECTED' named entity 'RATE' covid:arg/f8040dfc7d16650a47260dca344dbb97ff2c393a named entity 'HPLC' named entity 'septic shock' named entity 'high-performance liquid chromatography' named entity 'patients' named entity 'primary' named entity 'divided' named entity 'Controversies' named entity 'infections' named entity 'septic shock' named entity 'septic shock' named entity 'odds ratio' named entity 'neutrophil' named entity 'neutrophil' named entity 'bacteremia' named entity 'neutrophil' named entity 'bacteremia' named entity 'HPLC' named entity 'parenteral administration' named entity 'adjuvant therapies' named entity 'Klebsiella pneumoniae' named entity 'bacteremia' named entity 'assay' named entity 'aseptic conditions' named entity 'selenium' named entity 'carbapenem' named entity '3.5' named entity 'urinalysis' named entity 'infection' named entity '28 days' named entity 'sepsis' named entity 'written consent' named entity 'neutrophil' named entity '70 mM' named entity 'study protocol' named entity 'neutrophil' named entity 'cut-off' named entity 'bacteremia' named entity 'written consent' named entity 'statistically significant' named entity 'urine cultures' named entity 'odds ratio' named entity 'bacteremia' named entity 'prednisone' named entity 'odds ratio' named entity 'cell membranes' named entity 'abdomen' named entity '70 mM' named entity 'lipid peroxidation' named entity 'high-performance liquid chromatography' named entity 'adjuvant therapy' named entity 'pyrogen' named entity 'hepatic dysfunction' named entity 'antioxidants' named entity 'pathogens' named entity 'Kolmogorov' named entity 'Merck' named entity 'sepsis' named entity 'Gram-negative' named entity '70 mM' named entity 'azurophil granules' named entity 'neutrophils'

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