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About:
Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus
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An Entity of Type :
schema:ScholarlyArticle
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wasabi.inria.fr
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document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
New Facet based on Instances of this Class
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus
Creator
Albrecht, R
Baskin, C
Baskin, •
Bielefeldt-Ohmann, H
Bielefeldt-Ohmann, Á
Bielefeldt-Ohmann, •
García-Sastre, Á
García-Sastre, •
Katze, M
Katze, Á
Long, J
Pyles, J
Sabourin, C
Sabourin, P
Sabourin, •
Tolnay, A.-E
Tumpey, •
Source
PMC
abstract
The mechanisms responsible for virulence of influenza viruses in humans remain poorly understood. A prevailing hypothesis is that the highly pathogenic virus isolates cause a severe cytokinemia precipitating acute respiratory distress syndrome and multiple organ dysfunction syndrome. Cynomolgus macaques (Macaca fascicularis) infected with a human highly pathogenic avian influenza (HPAI) H5N1 virus isolate (A/Vietnam/1203/2004) or reassortants of human influenza virus A/Texas/36/91 (H1N1) containing genes from the 1918 pandemic influenza A (H1N1) virus developed severe pneumonia within 24 h postinfection. However, virus spread beyond the lungs was only detected in the H5N1 group, and signs of extrapulmonary tissue reactions, including microglia activation and sustained up-regulation of inflammatory markers, most notably hypoxia inducible factor-1α (HIF-1α), were largely limited to this group. Extrapulmonary pathology may thus contribute to the morbidities induced by H5N1 viruses.
has issue date
2010-04-07
(
xsd:dateTime
)
bibo:doi
10.1007/s00705-010-0662-8
bibo:pmid
20372944
has license
green-oa
sha1sum (hex)
f8396afa284a7dd545f0472e032c047c0982f60e
schema:url
https://doi.org/10.1007/s00705-010-0662-8
resource representing a document's title
Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus
has PubMed Central identifier
PMC2892232
has PubMed identifier
20372944
schema:publication
Archives of Virology
resource representing a document's body
covid:f8396afa284a7dd545f0472e032c047c0982f60e#body_text
is
schema:about
of
named entity 'AVIAN INFLUENZA A'
named entity 'MACAQUES'
named entity 'humans'
named entity 'Vietnam'
named entity 'tissue'
named entity 'Texas'
named entity 'precipitating'
named entity 'Macaca fascicularis'
named entity 'UNDERSTOOD'
named entity 'HUMANS'
named entity 'MULTIPLE ORGAN DYSFUNCTION SYNDROME'
named entity 'ISOLATES'
named entity 'HYPOTHESIS'
named entity 'SEVERE PNEUMONIA'
named entity 'VIRUS'
named entity 'THE LUNGS'
named entity 'HUMAN INFLUENZA VIRUS'
named entity 'MECHANISMS'
named entity 'INFLUENZA VIRUSES'
named entity 'CYNOMOLGUS'
named entity 'CYNOMOLGUS'
named entity 'RESPONSES'
named entity 'MACAQUES'
named entity 'PANDEMIC'
named entity 'SIGNS'
named entity 'HYPOXIA INDUCIBLE FACTOR'
named entity 'POORLY'
named entity 'MICROGLIA ACTIVATION'
named entity 'HIGHLY'
named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA'
named entity 'INFECTED'
named entity 'TISSUE'
named entity 'H5N1'
named entity 'SEVERE'
named entity 'VIRULENCE'
named entity 'INFLAMMATORY MARKERS'
named entity '1918'
named entity 'SPREAD'
named entity 'RESPONSIBLE'
named entity 'SUSTAINED'
named entity 'TISSUE'
named entity 'REACTIONS'
named entity 'PATHOGENIC'
named entity 'UP-REGULATION'
named entity 'INFECTED'
named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA'
named entity 'GROUP'
named entity 'HUMAN'
named entity '28A'
named entity 'DETECTED'
named entity 'CAUSE'
named entity 'INFLUENZA A'
named entity 'ISOLATE'
named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME'
named entity 'PRECIPITATING'
named entity 'BEYOND'
named entity 'GENES'
named entity 'INFLUENZA VIRUS A'
named entity 'CONTAINING'
named entity 'VIRUS'
named entity 'H5N1 VIRUS'
named entity 'INCLUDING'
covid:arg/f8396afa284a7dd545f0472e032c047c0982f60e
named entity 'pneumonia'
named entity 'pathogenic'
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