About: Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus

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About: Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus
Creator	Albrecht, R Baskin, C Baskin, • Bielefeldt-Ohmann, H Bielefeldt-Ohmann, Á Bielefeldt-Ohmann, • García-Sastre, Á García-Sastre, • Katze, M Katze, Á Long, J Pyles, J Sabourin, C Sabourin, P Sabourin, • Tolnay, A.-E Tumpey, •
Source	PMC
abstract	The mechanisms responsible for virulence of influenza viruses in humans remain poorly understood. A prevailing hypothesis is that the highly pathogenic virus isolates cause a severe cytokinemia precipitating acute respiratory distress syndrome and multiple organ dysfunction syndrome. Cynomolgus macaques (Macaca fascicularis) infected with a human highly pathogenic avian influenza (HPAI) H5N1 virus isolate (A/Vietnam/1203/2004) or reassortants of human influenza virus A/Texas/36/91 (H1N1) containing genes from the 1918 pandemic influenza A (H1N1) virus developed severe pneumonia within 24 h postinfection. However, virus spread beyond the lungs was only detected in the H5N1 group, and signs of extrapulmonary tissue reactions, including microglia activation and sustained up-regulation of inflammatory markers, most notably hypoxia inducible factor-1α (HIF-1α), were largely limited to this group. Extrapulmonary pathology may thus contribute to the morbidities induced by H5N1 viruses.
has issue date	2010-04-07(xsd:dateTime)
bibo:doi	10.1007/s00705-010-0662-8
bibo:pmid	20372944
has license	green-oa
sha1sum (hex)	f8396afa284a7dd545f0472e032c047c0982f60e
schema:url	https://doi.org/10.1007/s00705-010-0662-8
resource representing a document's title	Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus
has PubMed Central identifier	PMC2892232
has PubMed identifier	20372944
schema:publication	Archives of Virology
resource representing a document's body	covid:f8396afa284a7dd545f0472e032c047c0982f60e#body_text
is schema:about of	named entity 'AVIAN INFLUENZA A' named entity 'MACAQUES' named entity 'humans' named entity 'Vietnam' named entity 'tissue' named entity 'Texas' named entity 'precipitating' named entity 'Macaca fascicularis' named entity 'UNDERSTOOD' named entity 'HUMANS' named entity 'MULTIPLE ORGAN DYSFUNCTION SYNDROME' named entity 'ISOLATES' named entity 'HYPOTHESIS' named entity 'SEVERE PNEUMONIA' named entity 'VIRUS' named entity 'THE LUNGS' named entity 'HUMAN INFLUENZA VIRUS' named entity 'MECHANISMS' named entity 'INFLUENZA VIRUSES' named entity 'CYNOMOLGUS' named entity 'CYNOMOLGUS' named entity 'RESPONSES' named entity 'MACAQUES' named entity 'PANDEMIC' named entity 'SIGNS' named entity 'HYPOXIA INDUCIBLE FACTOR' named entity 'POORLY' named entity 'MICROGLIA ACTIVATION' named entity 'HIGHLY' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'INFECTED' named entity 'TISSUE' named entity 'H5N1' named entity 'SEVERE' named entity 'VIRULENCE' named entity 'INFLAMMATORY MARKERS' named entity '1918' named entity 'SPREAD' named entity 'RESPONSIBLE' named entity 'SUSTAINED' named entity 'TISSUE' named entity 'REACTIONS' named entity 'PATHOGENIC' named entity 'UP-REGULATION' named entity 'INFECTED' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'GROUP' named entity 'HUMAN' named entity '28A' named entity 'DETECTED' named entity 'CAUSE' named entity 'INFLUENZA A' named entity 'ISOLATE' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'PRECIPITATING' named entity 'BEYOND' named entity 'GENES' named entity 'INFLUENZA VIRUS A' named entity 'CONTAINING' named entity 'VIRUS' named entity 'H5N1 VIRUS' named entity 'INCLUDING' covid:arg/f8396afa284a7dd545f0472e032c047c0982f60e named entity 'pneumonia' named entity 'pathogenic'

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