About: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome

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About: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome
Creator	Paulo, Sao Fernanda, Maria Bento, Maria De Fatima, Maria De Paula, Yoshino De Souza, Ria Diniz, Rodrigues Fernandes, Vinicius Fink, Toledo Fonseca, Mota Galleti, Karine Joã, I Leal, Gabriela Lima, Alice Lima, Sylvia Litvinov, Nadia Palandri, Giovanna Pasmanik, Adriana Pinho, Renato Sanson, Camila Thais, I Valé, Juliana Watanabe, Andreia
topic	covid:f8537d51f24f7f49c66b28d5a5fd984d052b1055#this
source	Medline; PMC
abstract	OBJECTIVES: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C). METHODS: This cross-sectional study included 471 samples collected from 371 patients (age<18 years) suspected of having severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study group comprised 66/371 (18%) laboratory-confirmed pediatric COVID-19 patients: 61 (92.5%) patients tested positive on real-time reverse transcription-polymerase chain reaction tests for SARS-CoV-2, and 5 (7.5%) patients tested positive on serological tests. MIS-C was diagnosed according to the criteria of the Center for Disease Control. RESULTS: MIS-C was diagnosed in 6/66 (9%) patients. The frequencies of diarrhea, vomiting, and/or abdominal pain (67% vs. 22%, p=0.034); pediatric SARS (67% vs. 13%, p=0.008); hypoxemia (83% vs. 23%, p=0.006); and arterial hypotension (50% vs. 3%, p=0.004) were significantly higher in patients with MIS-C than in those without MIS-C. The frequencies of C-reactive protein levels >50 mg/L (83% vs. 25%, p=0.008) and D-dimer levels >1000 ng/mL (100% vs. 40%, p=0.007) and the median D-dimer, troponin T, and ferritin levels (p<0.05) were significantly higher in patients with MIS-C. The frequencies of pediatric intensive care unit admission (100% vs. 60%, p=0.003), mechanical ventilation (83% vs. 7%, p<0.001), vasoactive agent use (83% vs. 3%, p<0.001), shock (83% vs. 5%, p<0.001), cardiac abnormalities (100% vs. 2%, p<0.001), and death (67% vs. 3%, p<0.001) were also significantly higher in patients with MIS-C. Similarly, the frequencies of oxygen therapy (100% vs. 33%, p=0.003), intravenous immunoglobulin therapy (67% vs. 2%, p<0.001), aspirin therapy (50% vs. 0%, p<0.001), and current acute renal replacement therapy (50% vs. 2%, p=0.002) were also significantly higher in patients with MIS-C. Logistic regression analysis showed that the presence of MIS-C was significantly associated with gastrointestinal manifestations [odds ratio (OR)=10.98; 95%CI (95% confidence interval)=1.20-100.86; p=0.034] and hypoxemia [OR=16.85; 95%CI=1.34-211.80; p=0.029]. Further univariate analysis showed a positive association between MIS-C and death [OR=58.00; 95%CI=6.39-526.79; p<0.0001]. CONCLUSIONS: Pediatric patients with laboratory-confirmed COVID-19 with MIS-C had a severe clinical spectrum with a high mortality rate. Our study emphasizes the importance of investigating MIS-C in pediatric patients with COVID-19 presenting with gastrointestinal involvement and hypoxemia.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.6061/clinics/2020/e2209
bibo:pmid	32844958
has license	cc-by
sha1sum (hex)	f8537d51f24f7f49c66b28d5a5fd984d052b1055
schema:url	https://doi.org/10.6061/clinics/2020/e2209
resource representing a document's title	Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome
has PubMed Central identifier	PMC7426591
has PubMed identifier	32844958
schema:publication	Clinics (Sao Paulo)
resource representing a document's body	covid:f8537d51f24f7f49c66b28d5a5fd984d052b1055#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/f8537d51f24f7f49c66b28d5a5fd984d052b1055
is schema:about of	named entity 'patients' named entity 'inflammatory' named entity 'thrombocyte' named entity 'respiratory distress' named entity 'Werther' named entity 'Pediatric' named entity 'COVID-19' named entity 'MIS-C' named entity 'malaise' named entity 'immunocompromised' named entity 'pediatric' named entity 'MIS' named entity 'COVID-19' named entity 'dermatologic' named entity 'MIS-C' named entity 'MIS-C' named entity 'MIS-C' named entity 'vomiting' named entity 'demographic data' named entity 'liver fibrosis' named entity 'emergency room' named entity 'oxygen therapy' named entity 'diagnostic criteria' named entity 'MIS-C' named entity 'viral gastroenteritis' named entity 'fever' named entity 'cough' named entity 'cough' named entity 'diarrhea' named entity 'Neonates' named entity 'inpatient care' named entity 'COVID-19' named entity 'cutaneous' named entity 'hematopoietic stem cell transplantation' named entity 'troponin' named entity 'serological' named entity 'sore throat' named entity 'sample size' named entity 'pneumonia' named entity 'demographic data' named entity 'independent variables' named entity 'troponin' named entity 'ferritin' named entity 'mortality rate' named entity 'COVID' named entity 'gastrointestinal' named entity 'immunocompromised' named entity 'COVID-19' named entity 'MIS-C' named entity 'chronic diseases' named entity 'leucocyte' named entity 'neonatal' named entity 'neurological' named entity 'cardiac abnormalities' named entity 'dyspnea' named entity 'immunosuppressive' named entity 'pediatric patients'

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