About: The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777

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About: The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777
Creator	Pensaert, M Coussement, W Debouck, P
Source	Elsevier; PMC
abstract	Abstract Sixteen 2–3-days-old caesarean-derived, colostrum-deprived piglets were each dosed oro-nasally with 2 ml of a bacteria-free filtrate containing 104 pig-infectious-doses of CV 777. The piglets were killed at intervals of 12 to 120 h after infection. The coronvirus-like agent caused a local infection of the intestinal tract which resulted in villous atrophy, malabsorption and diarrhea. The pathogenesis of this infection was similar to that of transmissible gastroenteritis (TGE), a known coronaviral infection of pigs. However, where were some differences. By immunofluorescent staining, CV 777 antigens were not only detected in the epithelial cells covering the small intestinal villi, but also in the cells of the colonic surface epithelium. Occasional fluorescence was also seen in the small intestinal crypt epithelium, but the regenerative capacity of the crypts was not affected. The progress of intestinal epithelial cell infection by CV 777 was much slower than that in TGE, resulting in a longer incubation period and in less drastic epithelial cell destruction. The infection of regenerating cells occurred to a much higher degree during the late stage of a CV 777 infection than has been observed in TGE.
has issue date	1981-06-30(xsd:dateTime)
bibo:doi	10.1016/0378-1135(81)90007-9
has license	els-covid
sha1sum (hex)	f85aebc7b1ea0c39c8aba435a4cb30ce95f80fcb
schema:url	https://doi.org/10.1016/0378-1135%2881%2990007-9
resource representing a document's title	The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777
has PubMed Central identifier	PMC7117293
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:f85aebc7b1ea0c39c8aba435a4cb30ce95f80fcb#body_text
is schema:about of	named entity 'PIGS' named entity 'PATHOGENESIS' named entity '1981' named entity 'ENTERIC INFECTION' named entity 'CORONAVIRUS' named entity '777' named entity '777' named entity '777' named entity 'CORONAVIRUS' named entity 'INDUCED' named entity '777' named entity 'ENTERIC INFECTION' named entity 'INDUCED' named entity 'AGENT' named entity 'PATHOGENESIS' named entity 'LIKE' named entity 'PIGS' named entity 'LIKE' named entity 'AGENT' covid:arg/f85aebc7b1ea0c39c8aba435a4cb30ce95f80fcb named entity 'INFECTION' named entity 'PATHOGENESIS' named entity 'viruses' named entity 'Coronaviridae' named entity 'inoculation' named entity 'duodenum' named entity 'titer' named entity 'fluorescence' named entity 'immunofluorescence' named entity 'pathogenesis' named entity 'formalin' named entity 'pig' named entity 'jejunum' named entity 'functional disorder' named entity 'incubation period' named entity 'incubation period' named entity 'lung' named entity 'epithelial cell' named entity 'intestinal villi' named entity 'diarrhea' named entity 'epithelial cells' named entity 'inoculation' named entity 'pig' named entity 'fluorescing' named entity 'fluorescent' named entity 'distal' named entity 'intestinal villi' named entity 'pig' named entity 'infection' named entity 'severe diarrhea' named entity 'epithelial cells' named entity 'pig' named entity 'villous atrophy' named entity 'epithelial cells' named entity 'pig' named entity 'pig' named entity 'TGEV' named entity 'ocular micrometer' named entity 'Villous atrophy' named entity 'rotaviral' named entity 'viruses' named entity 'virus' named entity 'transmissible gastroenteritis virus' named entity 'morphology' named entity 'villi' named entity 'diarrhea' named entity 'small intestine' named entity 'spleen' named entity 'epithelial cells' named entity 'perfusion' named entity 'infection' named entity 'large intestine' named entity 'mesenteric lymph nodes' named entity 'villous' named entity 'fluorescence' named entity 'spleen' named entity 'inoculation' named entity 'small intestine' named entity 'undifferentiated cells' named entity 'small intestine' named entity 'histologic'

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