About: Characterization of two novel ADP ribosylation factors from giant freshwater prawn Macrobrachium rosenbergii and their responses to WSSV challenge

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About: Characterization of two novel ADP ribosylation factors from giant freshwater prawn Macrobrachium rosenbergii and their responses to WSSV challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of two novel ADP ribosylation factors from giant freshwater prawn Macrobrachium rosenbergii and their responses to WSSV challenge
Creator	Wang, Wen Huang, Ying Wang, Zheng Huang, Xin Ren, Qian Ren, Jie Ding, Zheng-Feng Lan, Jiang-Feng Tan, Jing-Min Yin, Shao-Wu
source	Elsevier; Medline; PMC
abstract	ADP-ribosylation factors (Arfs) are small GTP-binding proteins that have an essential function in intracellular trafficking and organelle structure. To date, little information is available on the Arfs in the economically important giant freshwater prawn Macrobrachium rosenbergii and their relationship to viral infection. Here we identified two Arf genes from M. rosenbergii (MrArf1 and MrArf2) for the first time. Phylogenetic analysis showed that MrArf1, together with MjArf1 from shrimp Marsupenaeus japonicus belonged to Class I Arfs. By contrast, MrArf2 didn't not match any of the Arfs classes of I/II/III, although it could be clustered with an Arf protein from M. japonicas called MjArfn, which may represent an analog of the Arf. MrArf1 was ubiquitously expressed in all the examined tissues, with the highest transcription level in the hepatopancreas, whereas MrArf2 was only highly expressed in the hepatopancreas and exhibited very low levels in the heart, stomach, gills and intestine. The expression level of MrArf1 in the gills was down-regulated post 24 h WSSV challenge, and reached the maximal level at 48 h. MrArf1 in the hepatopancreas went up from 24 to 48 h WSSV challenge. MrArf2 transcript in the gill also went down at 24 h and then was upregulated at 48 h WSSV challenge. MrArf2 increased significantly in the hepatopancreas 24 h after infection and then went down at 48 h WSSV challenge. RNAi results showed that knockdown of MrArf1 or MrArf2 could inhibit the expression of the envelope protein gene vp28 of the WSSV. So, it could be speculated that MrArf1 and MrArf2 might play important roles in the innate immune system against WSSV infection.
has issue date	2014-10-22(xsd:dateTime)
bibo:doi	10.1016/j.dci.2014.10.006
bibo:pmid	25451300
has license	no-cc
sha1sum (hex)	f8a291ed80559476dcef29048ec020c17e8029df
schema:url	https://doi.org/10.1016/j.dci.2014.10.006
resource representing a document's title	Characterization of two novel ADP ribosylation factors from giant freshwater prawn Macrobrachium rosenbergii and their responses to WSSV challenge
has PubMed Central identifier	PMC7124501
has PubMed identifier	25451300
schema:publication	Dev Comp Immunol
resource representing a document's body	covid:f8a291ed80559476dcef29048ec020c17e8029df#body_text
is schema:about of	named entity 'III' named entity 'knockdown' named entity 'giant' named entity 'prawn' named entity 'MACROBRACHIUM ROSENBERGII' named entity 'EXPRESSION LEVEL' named entity 'CLUSTERED' named entity 'MACROBRACHIUM ROSENBERGII' named entity 'MAXIMAL' named entity 'SHRIMP' named entity '28A' named entity 'ADP-RIBOSYLATION FACTORS' named entity 'ARF' named entity 'GILL' named entity 'REPRESENT' named entity 'RELATIONSHIP' named entity 'TRANSCRIPT' named entity 'METHODS' named entity 'GENES' named entity 'HIGHLY' named entity 'ECONOMICALLY IMPORTANT' named entity 'INTRACELLULAR' named entity 'CHALLENGE' named entity 'EXAMINED' named entity 'FIG' named entity 'TIME' named entity 'TRAFFICKING' named entity 'FUNCTION' named entity 'IDENTIFIED' named entity 'ENVELOPE PROTEIN' named entity 'VIRAL INFECTION' named entity 'HIGHEST' named entity 'GIANT FRESHWATER PRAWN' named entity 'GILLS' named entity 'CONTRAST' named entity 'INFECTION' named entity 'INCREASED' named entity 'CLASS I' named entity 'FRESHWATER' named entity 'HERE' named entity 'VERY LOW' named entity 'PLAY' named entity 'PHYLOGENETIC ANALYSIS' named entity 'WSSV' named entity 'PROTEIN ' named entity 'HAVE' named entity 'ORGANELLE STRUCTURE' named entity 'EXPRESSION' named entity 'HEPATOPANCREAS' named entity 'AVAILABLE' named entity 'UPREGULATED' named entity 'INFORMATION' named entity 'HEART' named entity 'ANALYSIS' named entity 'QRT-PCR' named entity 'TISSUES' named entity 'RESULTS' named entity 'LITTLE' named entity 'CLASSES' named entity 'CHALLENGE' named entity 'THEIR' named entity 'TRANSCRIPTION' named entity 'INTESTINE' named entity 'SMALL GTP-BINDING PROTEINS' named entity 'LEVELS' named entity 'IMPORTANT' named entity 'RNAI' named entity 'EXPRESSED' named entity 'USING' named entity 'PROTEIN GENE' named entity 'ANALOG' named entity 'GIANT'

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