About: The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

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About: The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
Creator	Luo, Rui Ge, Xing-Yi Wang, Qiong Li, Jin-Yan Qiu, Ye Liao, Ce-Heng Li, J-Yan Liao, C-Heng Tan, Wang Tan, Yong-Jun
source	Elsevier; Medline; PMC
abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus causing the pandemic of severe pneumonia (Coronavirus Disease 2019, COVID-19). SARS-CoV-2 is highly pathogenic in human, having posed immeasurable public health challenges to the world. Innate immune response is critical for the host defense against viral infection and the dysregulation of the host innate immune responses probably aggravates SARS-CoV-2 infection, contributing to the high morbidity and lethality of COVID-19. It has been reported that some coronavirus proteins play an important role in modulating innate immunity of the host, but few studies have been conducted on SARS-CoV-2. In this study, we screened the viral proteins of SARS-CoV-2 and found that the viral ORF6, ORF8 and nucleocapsid proteins were potential inhibitors of type I interferon signaling pathway, a key component for antiviral response of host innate immune. All the three proteins showed strong inhibition on type I interferon (IFN-β) and NF-κB-responsive promoter, further examination revealed that these proteins were able to inhibit the interferon-stimulated response element (ISRE) after infection with Sendai virus, while only ORF6 and ORF8 proteins were able to inhibit the ISRE after treatment with interferon beta. These findings would be helpful for the further study of the detailed signaling pathway and unveil the key molecular player that may be targeted.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2020.198074
bibo:pmid	32589897
has license	no-cc
sha1sum (hex)	f920f8681b01511b02cb0d9710e584a8dd16f3e3
schema:url	https://doi.org/10.1016/j.virusres.2020.198074
resource representing a document's title	The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
has PubMed Central identifier	PMC7309931
has PubMed identifier	32589897
schema:publication	Virus Res
resource representing a document's body	covid:f920f8681b01511b02cb0d9710e584a8dd16f3e3#body_text
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