About: Analysis of the effect of proton pump inhibitors on the course of common COVID-19

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis of the effect of proton pump inhibitors on the course of common COVID-19
Creator	Chen, Liang Ling, Yun Cn, Liang, Chen，chenliang@shphc Qian, Zhi-Ping Wu, Hai-Bing Zhang, Xiao-Yu
Source	MedRxiv
abstract	Background/aims: To evaluate the effect of proton pump inhibitors on the course of common COVID-19. Methods: Clinical data of common COVID-19 patients admitted to the Shanghai public health clinical center for treatment from January 20, 2020 to March 16, 2020 were collected. A retrospective study was conducted and the patients were divided into two groups according to whether they used proton pump inhibitors or not. The differences in SARS-CoV-2 clearance and hospital stay between the two groups were compared by univariate and multivariate analyses. Results: A total of 154 COVID-19 common cases were included in this study, including 80 males (51.9%), 35 patients (22.7%) in the proton pump inhibitors group, and 119 patients (77.3%) in the control group. In the proton pump inhibitors group and the control group, the duration of SARS-CoV-2 clearance were 7(6-9) and 7(6-11) days, and the duration of hospital stay was 21(16-25) and 20(15-26) days, respectively. There was no significant difference between the two groups in the cumulative incidence of SARS-CoV-2 clearance and the cumulative incidence of discharge, and the same after Propensity Score Match, all P > 0.05. Multivariate analysis suggested that chronic gastropathy prolonged the duration of SARS-CoV-2 clearance, the HR was 20.924(3.547-123.447). Hypertension, chronic obstructive pulmonary disease, chronic liver disease and malignant tumor all increased the duration of hospital stay for COVID-19, and the HR were 1.820 (1.073-3.085), 4.370 (1.205-15.844), 9.011 (2.681-30.290) and 5.270 (1.237-22.456), respectively; the duration of hospital stay in COVID-19 patients was shortened by SARS-CoV-2 clearance, and the HR was 0.907 (0.869-0.947); all P < 0.05. Conclusion: Proton pump inhibitors use have no effect on the prolonging or shortening of the course of adults hospitalized with COVID-19.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1101/2020.06.07.20124776
has license	medrxiv
sha1sum (hex)	f9452f1387491a707a183f73dccf8145e0fa82f1
schema:url	https://doi.org/10.1101/2020.06.07.20124776
resource representing a document's title	Analysis of the effect of proton pump inhibitors on the course of common COVID-19
resource representing a document's body	covid:f9452f1387491a707a183f73dccf8145e0fa82f1#body_text
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