About: Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation
Creator	Gao, Yu Bidanel, Jean-Pierre Bouffaud, Marcel Cossalter, Anne-Marie Flori, Laurence Laloë, Denis Leplat, Jean-Jacques Mercat, Marie-José Pinton, Philippe Rogel-Gaillard, Claire De Vaureix, Christiane Lefè Vre, François Lique Teillaud, Angé Lle Laffitte, Joë Oswald, Isabelle Tan Lemonnier, Gaë
Source	PMC
abstract	BACKGROUND: Increasing robustness via improvement of resistance to pathogens is a major selection objective in livestock breeding. As resistance traits are difficult or impossible to measure directly, potential indirect criteria are measures of immune traits (ITs). Our underlying hypothesis is that levels of ITs with no focus on specific pathogens define an individual's immunocompetence and thus predict response to pathogens in general. Since variation in ITs depends on genetic, environmental and probably epigenetic factors, our aim was to estimate the relative importance of genetics. In this report, we present a large genetic survey of innate and adaptive ITs in pig families bred in the same environment. METHODOLOGY/PRINCIPAL FINDINGS: Fifty four ITs were studied on 443 Large White pigs vaccinated against Mycoplasma hyopneumoniae and analyzed by combining a principal component analysis (PCA) and genetic parameter estimation. ITs include specific and non specific antibodies, seric inflammatory proteins, cell subsets by hemogram and flow cytometry, ex vivo production of cytokines (IFNα, TNFα, IL6, IL8, IL12, IFNγ, IL2, IL4, IL10), phagocytosis and lymphocyte proliferation. While six ITs had heritabilities that were weak or not significantly different from zero, 18 and 30 ITs had moderate (0.1<h2≤0.4) or high (h2>0.4) heritability values, respectively. Phenotypic and genetic correlations between ITs were weak except for a few traits that mostly include cell subsets. PCA revealed no cluster of innate or adaptive ITs. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that variation in many innate and adaptive ITs is genetically controlled in swine, as already reported for a smaller number of traits by other laboratories. A limited redundancy of the traits was also observed confirming the high degree of complementarity between innate and adaptive ITs. Our data provide a genetic framework for choosing ITs to be included as selection criteria in multitrait selection programmes that aim to improve both production and health traits.
has issue date	2011-07-29(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0022717
bibo:pmid	21829490
has license	cc-by
sha1sum (hex)	f9572dc31ce0512cc966d43fbe693656af18a03c
schema:url	https://doi.org/10.1371/journal.pone.0022717
resource representing a document's title	Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation
has PubMed Central identifier	PMC3146468
has PubMed identifier	21829490
schema:publication	PLoS One
resource representing a document's body	covid:f9572dc31ce0512cc966d43fbe693656af18a03c#body_text
is schema:about of	named entity 'GENETIC VARIATION' named entity 'TRAITS' named entity 'RESISTANCE TO' named entity 'HYPOTHESIS' named entity 'SURVEY' named entity 'FAMILIES' named entity 'OBJECTIVE' named entity 'LEVELS' named entity 'LIVESTOCK' named entity 'RELATIVE' named entity 'SPECIFIC' named entity 'PROBABLY' named entity 'INDIVIDUAL' named entity 'BRED' named entity 'DIFFICULT' named entity 'PRESENT' named entity 'INCREASING' named entity 'ADAPTIVE' named entity 'IMMUNE' named entity 'IS A' named entity 'RESPONSE TO' named entity 'AIM' named entity 'GENETIC' named entity 'OUR' named entity 'BACKGROUND' named entity 'REPORT' named entity 'INDIRECT' named entity 'LARGE' named entity 'TRAITS' named entity 'POTENTIAL' named entity 'VARIATION' named entity 'ENVIRONMENT' named entity 'FOCUS' named entity 'LIMITED' named entity 'IMMUNITY' named entity 'A MAJOR' named entity 'EPIGENETIC' named entity 'MEASURES' named entity 'PIGS' named entity 'COVARIATION' named entity 'ESTIMATE' named entity 'SELECTION' named entity 'GENETICS' named entity 'UNDERLYING' named entity 'ITS' named entity 'RESISTANCE' named entity 'BREEDING' named entity 'PIG' named entity '27S' named entity 'TO MEASURE' named entity 'ENVIRONMENTAL' named entity 'IMPOSSIBLE' named entity 'CRITERIA' named entity 'DIRECTLY' named entity 'IMPROVEMENT' named entity 'GENERAL' named entity 'PATHOGENS' named entity 'IMMUNOCOMPETENCE' named entity 'PREDICT' covid:arg/f9572dc31ce0512cc966d43fbe693656af18a03c named entity 'cytokine' named entity 'CD16' named entity 'France' named entity 'lymphocyte' named entity 'DMEM' named entity 'CD8 +'

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