About: Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders
Creator	Edwards, Kathryn Finelli, Lyn Ampofo, Krow Bramley, Anna Jain, Seema Peacock, Georgina Anderson, Evan Arnold, Sandra Drph, Grijalva, Carlos Mccullers, Jonathan Millman, Alexander Pavia, Andrew Williams, Derek
Source	Elsevier; Medline; PMC
abstract	Objective To describe and compare the clinical characteristics, outcomes, and etiology of pneumonia among children hospitalized with community-acquired pneumonia (CAP) with neurologic disorders, non-neurologic underlying conditions, and no underlying conditions. Study design Children <18 years old hospitalized with clinical and radiographic CAP were enrolled at 3 US children's hospitals. Neurologic disorders included cerebral palsy, developmental delay, Down syndrome, epilepsy, non-Down syndrome chromosomal abnormalities, and spinal cord abnormalities. We compared the epidemiology, etiology, and clinical outcomes of CAP in children with neurologic disorders with those with non-neurologic underlying conditions, and those with no underlying conditions using bivariate, age-stratified, and multivariate logistic regression analyses. Results From January 2010-June 2012, 2358 children with radiographically confirmed CAP were enrolled; 280 (11.9%) had a neurologic disorder (52.1% of these individuals also had non-neurologic underlying conditions), 934 (39.6%) had non-neurologic underlying conditions only, and 1144 (48.5%) had no underlying conditions. Children with neurologic disorders were older and more likely to require intensive care unit (ICU) admission than children with non-neurologic underlying conditions and children with no underlying conditions; similar proportions were mechanically ventilated. In age-stratified analysis, children with neurologic disorders were less likely to have a pathogen detected than children with non-neurologic underlying conditions. In multivariate analysis, having a neurologic disorder was associated with ICU admission for children ≥2 years of age. Conclusions Children with neurologic disorders hospitalized with CAP were less likely to have a pathogen detected and more likely to be admitted to the ICU than children without neurologic disorders.
has issue date	2016-06-30(xsd:dateTime)
bibo:doi	10.1016/j.jpeds.2016.02.049
bibo:pmid	27017483
has license	els-covid
sha1sum (hex)	f98f4f3b3b3a0e0ba96edf39219e8b0eb0c65a16
schema:url	https://doi.org/10.1016/j.jpeds.2016.02.049
resource representing a document's title	Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders
has PubMed Central identifier	PMC4897771
has PubMed identifier	27017483
schema:publication	The Journal of Pediatrics
resource representing a document's body	covid:f98f4f3b3b3a0e0ba96edf39219e8b0eb0c65a16#body_text
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