About: Symptomatic and Asymptomatic Respiratory Viral Infections in the First Year of Life: Association With Acute Otitis Media Development

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Symptomatic and Asymptomatic Respiratory Viral Infections in the First Year of Life: Association With Acute Otitis Media Development
Creator	Chonmaitree, Tasnee Jennings, Kristofer Loeffelholz, Michael Alvarez-Fernandez, Pedro Trujillo, Rocio Marom, Tal Mccormick, David Miller, Aaron Patel, Janak Pyles, Richard
source	Medline; PMC
abstract	Background. Sensitive diagnostic assays have increased the detection of viruses in asymptomatic individuals. The clinical significance of asymptomatic respiratory viral infection in infants is unknown. Methods. High-throughput, quantitative polymerase chain reaction assays were used to detect 13 common respiratory viruses from nasopharyngeal specimens collected during 2028 visits from 362 infants followed from near birth up to 12 months of age. Specimens were collected at monthly interval (months 1–6 and month 9) and during upper respiratory tract infection (URTI) episodes. Subjects were followed closely for acute otitis media (AOM) development. Results. Viruses were detected in 76% of 394 URTI specimens and 27% of asymptomatic monthly specimens. Rhinovirus was detected most often; multiple viruses were detected in 29% of the specimens. Generalized mixed-model analyses associated symptoms with increasing age and female sex; detection of respiratory syncytial virus (RSV), influenza, rhinovirus, metapneumovirus, and adenovirus was highly associated with symptoms. Increasing age was also associated with multiple virus detection. Overall, 403 asymptomatic viral infections in 237 infants were identified. Viral load was significantly higher in URTI specimens than asymptomatic specimens but did not differentiate cases of URTI with and without AOM complication. The rate of AOM complicating URTI was 27%; no AOM occurred following asymptomatic viral infections. AOM development was associated with increasing age and infection with RSV, rhinovirus, enterovirus, adenovirus, and bocavirus. Conclusions. Compared to symptomatic infection, asymptomatic viral infection in infants is associated with young age, male sex, low viral load, specific viruses, and single virus detection. Asymptomatic viral infection did not result in AOM.
has issue date	2014-09-09(xsd:dateTime)
bibo:doi	10.1093/cid/ciu714
bibo:pmid	25205769
has license	bronze-oa
sha1sum (hex)	f998dab60e13c3df179653ab1f8014863e544ba1
schema:url	https://doi.org/10.1093/cid/ciu714
resource representing a document's title	Symptomatic and Asymptomatic Respiratory Viral Infections in the First Year of Life: Association With Acute Otitis Media Development
has PubMed Central identifier	PMC4318943
has PubMed identifier	25205769
schema:publication	Clinical Infectious Diseases
resource representing a document's body	covid:f998dab60e13c3df179653ab1f8014863e544ba1#body_text
is schema:about of	named entity 'viruses' named entity 'Background' named entity 'First' named entity 'VIRAL INFECTIONS' named entity 'UNKNOWN' named entity 'CLINICAL SIGNIFICANCE' named entity 'INDIVIDUALS' named entity 'DETECTION' named entity 'BACKGROUND' named entity 'VIRUSES' named entity 'ASYMPTOMATIC' named entity 'RESPIRATORY' named entity 'ASSOCIATION' named entity 'LIFE' named entity 'DEVELOPMENT' named entity 'ACUTE OTITIS MEDIA' named entity 'SYMPTOMATIC' named entity 'YEAR' named entity 'INCREASED' named entity 'SENSITIVE' named entity 'INFANTS' named entity 'DIAGNOSTIC' named entity 'ASYMPTOMATIC' named entity 'HAVE' named entity 'RESPIRATORY VIRAL INFECTION' covid:arg/f998dab60e13c3df179653ab1f8014863e544ba1 named entity 'asymptomatic' named entity 'infants' named entity 'respiratory tract' named entity 'nasopharyngeal' named entity 'URTI' named entity 'Eustachian tubes' named entity 'AOM' named entity 'asymptomatic' named entity 'risk factor' named entity 'clinical significance' named entity 'asymptomatic' named entity 'viral infection' named entity 'detection' named entity 'viral infection' named entity 'respiratory tract' named entity 'Rhinovirus' named entity 'URTI' named entity 'cigarette' named entity 'URTI' named entity 'OC43' named entity 'asymptomatic' named entity 'AOM' named entity 'AOM' named entity 'asymptomatic' named entity 'acute bacterial sinusitis' named entity 'asymptomatic' named entity 'Eustachian tube' named entity 'virus' named entity 'URTI' named entity 'environmental factors' named entity 'asymptomatic' named entity 'viral persistence' named entity 'AOM' named entity 'viruses' named entity 'metapneumovirus' named entity 'AOM' named entity 'enterovirus' named entity 'family history' named entity 'LRTI' named entity 'viral load' named entity 'asymptomatic infection' named entity 'URTI' named entity 'respiratory viral infections' named entity 'correlation' named entity 'infection' named entity 'mixed model'

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