About: High host density favors greater virulence: a model of parasite–host dynamics based on multi-type branching processes

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About: High host density favors greater virulence: a model of parasite–host dynamics based on multi-type branching processes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	High host density favors greater virulence: a model of parasite–host dynamics based on multi-type branching processes
Creator	Borovkov, K Day, R Day, · Rice, ·
Source	Medline; PMC
abstract	We use a multitype continuous time Markov branching process model to describe the dynamics of the spread of parasites of two types that can mutate into each other in a common host population. While most mathematical models for the virulence of infectious diseases focus on the interplay between the dynamics of host populations and the optimal characteristics for the success of the pathogen, our model focuses on how pathogen characteristics may change at the start of an epidemic, before the density of susceptible hosts decline. We envisage animal husbandry situations where hosts are at very high density and epidemics are curtailed before host densities are much reduced. The use of three pathogen characteristics: lethality, transmissibility and mutability allows us to investigate the interplay of these in relation to host density. We provide some numerical illustrations and discuss the effects of the size of the enclosure containing the host population on the encounter rate in our model that plays the key role in determining what pathogen type will eventually prevail. We also present a multistage extension of the model to situations where there are several populations and parasites can be transmitted from one of them to another. We conclude that animal husbandry situations with high stock densities will lead to very rapid increases in virulence, where virulent strains are either more transmissible or favoured by mutation. Further the process is affected by the nature of the farm enclosures.
has issue date	2012-03-30(xsd:dateTime)
bibo:doi	10.1007/s00285-012-0526-9
bibo:pmid	22461126
has license	no-cc
sha1sum (hex)	f9bab971b7a0cf9d130f86dcb439981f280e2276
schema:url	https://doi.org/10.1007/s00285-012-0526-9
resource representing a document's title	High host density favors greater virulence: a model of parasite–host dynamics based on multi-type branching processes
has PubMed Central identifier	PMC7080088
has PubMed identifier	22461126
schema:publication	J Math Biol
resource representing a document's body	covid:f9bab971b7a0cf9d130f86dcb439981f280e2276#body_text
is schema:about of	named entity 'PARASITE' named entity 'DYNAMICS' named entity 'BRANCHING' named entity 'PROCESSES' named entity 'MUTATE' named entity 'PARASITES' named entity 'FARM' named entity 'TIME' named entity 'MULTI' named entity 'LETHALITY' named entity 'BRANCHING PROCESS' named entity 'MATHEMATICAL MODELS' named entity 'WHERE' named entity 'STOCK' named entity 'EPIDEMICS' named entity 'RATE' named entity 'ROLE' named entity 'WHAT' named entity 'OPTIMAL' named entity 'SPREAD' named entity 'ANIMAL HUSBANDRY' named entity 'DISCUSS' named entity 'PROCESS' named entity 'RAPID' named entity 'HIGH' named entity 'GREATER' named entity 'TYPE' named entity 'START' named entity 'POPULATIONS' named entity 'HOST' named entity 'VIRULENCE' named entity 'MODEL OF' named entity 'BASED' named entity 'EFFECTS' named entity 'DYNAMICS' named entity 'ALLOWS' named entity 'HIGH' named entity 'VIRULENCE' named entity 'TRANSMITTED' named entity 'TO DESCRIBE' named entity 'DENSITY' named entity 'SUCCESS' named entity 'ENCOUNTER' named entity 'LEAD' named entity 'FOCUS' named entity 'INCREASES' named entity 'SUSCEPTIBLE' named entity 'TO INVESTIGATE' named entity 'VERY HIGH' named entity 'PREVAIL' named entity 'DENSITIES' named entity 'KEY' named entity 'INFECTIOUS DISEASES' named entity 'MUTATION' named entity 'USE' named entity 'PROVIDE' named entity 'HOST' named entity 'PATHOGEN' named entity 'STRAINS' named entity 'AFFECTED' named entity 'DECLINE' named entity 'ENCLOSURE' named entity 'EITHER' named entity 'OUR' named entity 'CHANGE' named entity 'SIZE' named entity 'A COMMON' named entity 'CONCLUDE' named entity 'PROCESS MODEL' named entity 'CONTINUOUS' named entity 'NUMERICAL' named entity 'HOST POPULATION' named entity 'NATURE' named entity 'PRESENT' named entity 'EPIDEMIC' named entity 'TYPE' named entity 'CHARACTERISTICS' named entity 'ONE OF'

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