About: Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2

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About: Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2
Creator	Yang, Yan He, Jun Li, Li Chen, Cheng Su, Dan Chen, Yiping Zhang, Changhui
Source	PMC
abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of a potentially fatal disease named coronavirus disease 2019 (COVID-19), has raised significant public health concerns globally. To date, the COVID-19 pandemic has caused millions of people to be infected with SARS-CoV-2 worldwide. It has been known since the 2003 SARS epidemic that coronaviruses (CoVs) have large RNA genomes, the replication of which requires an RNA-dependent RNA replication/transcription complex. CoV nonstructural proteins (Nsps) play pivotal roles in the assembly of this complex and associated enzymatic functions in virus genomic replication. Several smaller nonenzymatic Nsps assist with RNA-dependent RNA polymerase function. In this study, we determined the structure of SARS-CoV-2 nonstructural protein 9 (nsp9), an RNA-binding protein that is essential for CoV replication. Its homotetrameric structure with two stable dimeric interfaces provids a structural basis for understanding the mechanisms of RNA-binding protein self-assembly, which may be essential for the regulation of viral RNA replication and transcription.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1186/s43556-020-00005-0
has license	cc-by
sha1sum (hex)	f9c709965f410d9fff24c6fc7d76e09cf2c8fd68
schema:url	https://doi.org/10.1186/s43556-020-00005-0
resource representing a document's title	Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2
has PubMed Central identifier	PMC7438161
schema:publication	Mol Biomed
resource representing a document's body	covid:f9c709965f410d9fff24c6fc7d76e09cf2c8fd68#body_text
is schema:about of	named entity 'RNA' named entity 'RNA' named entity 'caused' named entity 'fatal' named entity 'structure' named entity 'replication' named entity 'complex' named entity 'SARS-CoV-2' named entity 'stable' named entity 'replication' named entity 'homotetrameric' named entity 'replication' named entity 'helicase' named entity 'betacoronaviruses' named entity 'SARS-CoV-2' named entity 'infection' named entity 'non-denaturing' named entity 'Coronavirus disease 2019' named entity 'oligosaccharide' named entity 'tetramer' named entity 'essential' named entity 'nonstructural proteins' named entity 'RNA replication' named entity 'causative agent' named entity 'self-assembly' named entity 'RNA' named entity 'transcription' named entity 'RNA-binding protein' named entity 'homotetrameric' named entity 'nonstructural protein' named entity 'SARS-CoV-2' named entity 'Severe acute respiratory syndrome coronavirus' named entity 'Coronavirus' named entity 'ssDNA' named entity 'nsp5' named entity 'N-terminal extension' named entity 'single-stranded RNA' named entity 'protein' named entity 'mutation' named entity 'β-strand' named entity 'A280' named entity 'TBE' named entity 'positive-sense RNA' named entity 'virus' named entity 'SARS-CoV-2' named entity 'molecule' named entity 'SARS-CoV-2' named entity 'DSSP' named entity 'Tris-HCl' named entity 'CCP4' named entity 'SARS-CoV-2' named entity 'IBV' named entity 'CoV' named entity 'previously identified' named entity 'Mutation' named entity 'CoV' named entity 'Betacoronavirus' named entity 'SARS-CoV-2' named entity 'Qiagen' named entity 'α-helix' named entity 'nucleic acid' named entity 'China' named entity 'α-helix' named entity 'Single-stranded' named entity 'interact' named entity 'protomers' named entity 'hydrogen bonds' named entity 'SUMO' named entity 'porcine epidemic diarrhea virus' named entity 'SARS-CoV-2' named entity 'RNA' named entity 'glycerol' named entity 'World Health Organization' named entity 'porcine epidemic diarrhea virus' named entity 'SARS-CoV' named entity 'homologs' named entity 'genome'

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