About: Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity

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About: Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity
Creator	Bozza, Fernando Cruz, Oswaldo Bozza, Patricia Assis, Edson Azeredo, Elzinandes Kubelka, Claire Nogueira, Rita Mo Zagne, Sonia
source	PMC
abstract	BACKGROUND: Dengue virus pathogenesis is not yet fully understood and the identification of patients at high risk for developing severe disease forms is still a great challenge in dengue patient care. During the present study, we evaluated prospectively the potential of cytokines present in plasma from patients with dengue in stratifying disease severity. METHODS: Seventeen-cytokine multiplex fluorescent microbead immunoassay was used for the simultaneous detection in 59 dengue patients. GLM models using bimodal or Gaussian family were determined in order to associate cytokines with clinical manifestations and laboratory diagnosis. RESULTS: IL-1β, IFN-γ, IL-4, IL-6, IL-13, IL-7 and GM-CSF were significantly increased in patients with severe clinical manifestations (severe dengue) when compared to mild disease forms (mild dengue). In contrast, increased MIP-1β levels were observed in patients with mild dengue. MIP-1β was also associated with CD56+NK cell circulating rates. IL-1β, IL-8, TNF-α and MCP-1 were associated with marked thrombocytopenia. Increased MCP-1 and GM-CSF levels correlated with hypotension. Moreover, MIP-1β and IFN-γ were independently associated with both dengue severity and disease outcome. CONCLUSION: Our data demonstrated that the use of a multiple cytokine assay platform was suitable for identifying distinct cytokine profiles associated with the dengue clinical manifestations and severity. MIP-β is indicated for the first time as a good prognostic marker in contrast to IFN-γ that was associated with disease severity.
has issue date	2008-06-25(xsd:dateTime)
bibo:doi	10.1186/1471-2334-8-86
bibo:pmid	18578883
has license	cc-by
sha1sum (hex)	f9e25b3fb07c1338b5a21c36014e295ab14ca736
schema:url	https://doi.org/10.1186/1471-2334-8-86
resource representing a document's title	Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity
has PubMed Central identifier	PMC2474613
has PubMed identifier	18578883
schema:publication	BMC Infect Dis
resource representing a document's body	covid:f9e25b3fb07c1338b5a21c36014e295ab14ca736#body_text
is schema:about of	named entity 'pathogenesis' named entity 'GREAT' named entity 'patients' named entity 'plasma' named entity 'high risk' named entity 'stratifying' named entity 'patients' named entity 'patient care' named entity 'MIP-1β' named entity 'prognosis' named entity 'dengue fever' named entity 'immunoregulation' named entity 'cytokine' named entity 'IL-12' named entity 'physical examination' named entity 'cytokine' named entity 'NK cells' named entity 'MCP-1' named entity 'odds ratio' named entity 'Cytokine' named entity 'IFN-γ' named entity 'platelet counts' named entity 'IFN-α' named entity 'cryopreserved' named entity 'thrombocytopenia' named entity 'protein' named entity 'dengue' named entity 'haemorrhage' named entity 'dynamic range' named entity 'sepsis' named entity 'cytokines' named entity 'blood samples' named entity 'cytokine' named entity 'IL-2' named entity 'chemoattractant' named entity 'IL-8' named entity 'Hepatitis' named entity 'IFN-γ' named entity 'plasma' named entity 'granulocyte' named entity 'virus' named entity 'serotype' named entity 'Mann-Whitney U test' named entity 'internal haemorrhage' named entity 'cytokine' named entity 'sepsis' named entity 'dengue' named entity 'plasma' named entity 'monocytes' named entity 'sample size' named entity 'inflammatory response' named entity 'dengue' named entity 'febrile' named entity 'MIP-1β' named entity 'cytokines' named entity 'odds ratio' named entity 'odds ratio' named entity 'MIP-1β' named entity 'cytokine' named entity 'plasma' named entity 'viremia' named entity 'analyte' named entity 'dengue' named entity 'cytokine' named entity 'IFN-γ' named entity 'IL-7' named entity 'IFN-γ' named entity 'pathogenesis' named entity 'informed consent' named entity 'Oswaldo Cruz Foundation' named entity 'IFN-γ' named entity '4.3' named entity 'disease outcome' named entity 'pathophysiological'

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