About: Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation

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About: Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation
Creator	Zeng, Fanya Hon, Chung-Chau Yip, Chi-Wai Yeung, Yin-Shan Chow, Ken Leung, Frederick Ma, Iris
Source	Elsevier; Medline; PMC
abstract	Abstract We have previously demonstrated that over-expression of spike protein (S) of severe acute respiratory syndrome coronavirus (SARS-CoV) or its C-terminal subunit (S2) is sufficient to induce apoptosis in vitro. To further investigate the possible roles of S2 in SARS-CoV-induced apoptosis and pathogenesis of SARS, we characterized the host expression profiles induced upon S2 over-expression in Vero E6 cells by oligonucleotide microarray analysis. Possible activation of mitochondrial apoptotic pathway in S2 expressing cells was suggested, as evidenced by the up-regulation of cytochrome c and down-regulation of the Bcl-2 family anti-apoptotic members. Inhibition of Bcl-2-related anti-apoptotic pathway was further supported by the diminution of S2-induced apoptosis in Vero E6 cells over-expressing Bcl-xL. In addition, modulation of CCN E2 and CDKN 1A implied the possible control of cell cycle arrest at G1/S phase. This study is expected to extend our understanding on the pathogenesis of SARS at a molecular level.
has issue date	2008-02-05(xsd:dateTime)
bibo:doi	10.1016/j.virol.2007.09.016
bibo:pmid	17961624
has license	els-covid
sha1sum (hex)	fa4ec420eb5b0075e7b6e5cced55e5a3d32692ce
schema:url	https://doi.org/10.1016/j.virol.2007.09.016
resource representing a document's title	Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation
has PubMed Central identifier	PMC7103328
has PubMed identifier	17961624
schema:publication	Virology
resource representing a document's body	covid:fa4ec420eb5b0075e7b6e5cced55e5a3d32692ce#body_text
is schema:about of	named entity 'up-regulation' named entity 'Bcl-2 family' named entity 'Vero' named entity 'MICROARRAY ANALYSIS' named entity 'CYTOCHROME C' named entity 'APOPTOSIS' named entity 'ADDITION' named entity 'OLIGONUCLEOTIDE MICROARRAY' named entity 'DEMONSTRATED' named entity 'C-TERMINAL' named entity 'IN VITRO' named entity 'BCL-2 FAMILY' named entity 'CONTROL' named entity 'CDKN' named entity 'STUDY' named entity 'ACTIVATION' named entity 'SARS-COV' named entity 'PATHOGENESIS' named entity 'ROLES' named entity 'VERO' named entity 'PHASE' named entity 'HOST' named entity '28S' named entity 'VERO' named entity 'PREVIOUSLY' named entity 'INHIBITION' named entity 'PROTEIN ' named entity 'DOWN-REGULATION' named entity 'BCL-XL' named entity 'RELATED' named entity 'THE UP' named entity 'SUFFICIENT' named entity 'POSSIBLE' named entity 'LEVEL' named entity 'SUBUNIT' named entity 'INDUCE' named entity 'MITOCHONDRIAL APOPTOTIC PATHWAY' named entity 'EXPRESSION' named entity 'MEMBERS' named entity 'CELL CYCLE ARREST' covid:arg/fa4ec420eb5b0075e7b6e5cced55e5a3d32692ce named entity 'INDUCED' named entity 'EXTEND' named entity 'CHARACTERIZED' named entity 'CELLS' named entity 'VIRAL' named entity 'INSIGHTS' named entity 'REGULATION OF APOPTOSIS' named entity 'SARS-COV' named entity 'CCN' named entity 'BCL-2' named entity 'EXPECTED' named entity 'SPIKE PROTEIN' named entity 'MOLECULAR' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'CELLS' named entity 'MODULATION' named entity 'OUR' named entity 'HAVE' named entity 'DIMINUTION' named entity 'SUPPORTED' named entity 'INVESTIGATE' named entity 'UNDERSTANDING' named entity 'SUBUNIT' named entity 'APOPTOTIC' named entity 'UP-REGULATION' named entity 'SARS' named entity 'TRANSCRIPTIONAL PROFILING' named entity 'PROLIFERATION' named entity 'PATHWAY' named entity 'ITS' named entity 'down-regulation' named entity 'induced' named entity 'cell cycle' named entity 'apoptosis'

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