About: The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil
Creator	Virji, Mumtaz Agnew, Christopher Borodina, Elena Conners, Rebecca Lammie, Donna Wess, Timothy Brady, R Burton, Nicholas Catto, Lucy Clarke, Anthony Daniell, Sarah Hill, Darryl Sessions, Richard
Source	PMC
abstract	Moraxella catarrhalis is a ubiquitous human-specific bacterium commonly associated with upper and lower respiratory tract infections, including otitis media, sinusitis and chronic obstructive pulmonary disease. The bacterium uses an autotransporter protein UspA1 to target an important human cellular receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Using X-ray crystallography, we show that the CEACAM1 receptor-binding region of UspA1 unusually consists of an extended, rod-like left-handed trimeric coiled-coil. Mutagenesis and binding studies of UspA1 and the N-domain of CEACAM1 have been used to delineate the interacting surfaces between ligand and receptor and guide assembly of the complex. However, solution scattering, molecular modelling and electron microscopy analyses all indicate that significant bending of the UspA1 coiled-coil stalk also occurs. This explains how UspA1 can engage CEACAM1 at a site far distant from its head group, permitting closer proximity of the respective cell surfaces during infection.
has issue date	2008-06-18(xsd:dateTime)
bibo:doi	10.1038/emboj.2008.101
bibo:pmid	18497748
has license	cc-by-nc-nd
sha1sum (hex)	fa9460f462e92e3ccbecc0e9fe406b886b7c1e35
schema:url	https://doi.org/10.1038/emboj.2008.101
resource representing a document's title	The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil
has PubMed Central identifier	PMC2396876
has PubMed identifier	18497748
schema:publication	EMBO J
resource representing a document's body	covid:fa9460f462e92e3ccbecc0e9fe406b886b7c1e35#body_text
is schema:about of	named entity 'CELLULAR' named entity 'DELINEATE' named entity 'ASSEMBLY' named entity 'GUIDE' named entity 'N-DOMAIN' named entity 'SITE' named entity 'ELECTRON MICROSCOPY' named entity 'HAVE' named entity 'INTERACTING' named entity 'LIGAND' named entity 'RECEPTOR' named entity 'CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1' named entity 'LEFT' named entity 'USES' named entity 'TARGET' named entity 'IMPORTANT' named entity 'IS A' named entity 'BACTERIUM' named entity 'HEAD' named entity 'UBIQUITOUS' named entity 'commonly' named entity 'sinusitis' named entity 'adhesin' named entity 'coiled-coil' named entity 'deformable' named entity 'trimeric' named entity 'COILED-COIL' covid:arg/fa9460f462e92e3ccbecc0e9fe406b886b7c1e35 named entity 'COMPLEX' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'X-RAY CRYSTALLOGRAPHY' named entity 'SOLUTION' named entity 'BINDS' named entity 'CEACAM1' named entity 'FAR' named entity 'INCLUDING' named entity 'CELL' named entity 'PROTEIN ' named entity 'MORAXELLA' named entity 'ADHESIN' named entity 'RECEPTOR' named entity 'ITS' named entity 'MOLECULAR MODELLING' named entity 'STUDIES' named entity 'SPECIFIC' named entity 'BINDING REGION' named entity 'STALK' named entity 'SIGNIFICANT' named entity 'HOW' named entity 'USED' named entity 'SCATTERING' named entity 'ASSOCIATED WITH' named entity 'HUMAN' named entity 'MORAXELLA CATARRHALIS' named entity 'DISTANT FROM' named entity 'COILED-COIL' named entity 'INFECTION' named entity 'ROD-LIKE' named entity 'SURFACES' named entity 'GROUP' named entity 'EXTENDED' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'OTITIS MEDIA' named entity 'PROXIMITY' named entity 'HUMAN' named entity 'UPPER' named entity 'SINUSITIS' named entity 'BINDING' named entity 'ENGAGE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software