About: Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling

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About: Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling
Creator	Huang, Yong Ding, Li Tong, Dewen Du, Qian Zhao, Xiaomin Song, Xiangjun Zhang, Wenlong Zhang, Hongling Dong, Feng
Source	Elsevier; Medline; PMC
abstract	Abstract Transmissible gastroenteritis virus (TGEV), an enteropathogenic coronavirus, causes severe lethal watery diarrhea and dehydration in piglets. Previous studies indicate that TGEV infection induces cell apoptosis in host cells. In this study, we investigated the roles and regulation of reactive oxygen species (ROS) in TGEV-activated apoptotic signaling. The results showed that TGEV infection induced ROS accumulation, whereas UV-irradiated TGEV did not promote ROS accumulation. In addition, TGEV infection lowered mitochondrial transmembrane potential in PK-15 cell line, which could be inhibited by ROS scavengers, pyrrolidinedithiocarbamic (PDTC) and N-acetyl-l-cysteine (NAC). Furthermore, the two scavengers significantly inhibited the activation of p38 MAPK and p53 and further blocked apoptosis occurrence through suppressing the TGEV-induced Bcl-2 reduction, Bax redistribution, cytochrome c release and caspase-3 activation. These results suggest that oxidative stress pathway might be a key element in TGEV-induced apoptosis and TGEV pathogenesis.
has issue date	2013-12-06(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2013.10.164
bibo:pmid	24225120
has license	els-covid
sha1sum (hex)	faa567ed8f896e342be7b1a152ecec6843332b2d
schema:url	https://doi.org/10.1016/j.bbrc.2013.10.164
resource representing a document's title	Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling
has PubMed Central identifier	PMC7092821
has PubMed identifier	24225120
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:faa567ed8f896e342be7b1a152ecec6843332b2d#body_text
is schema:about of	named entity 'diarrhea' named entity 'infection' named entity 'promote' named entity 'p53' named entity 'REGULATION' named entity 'CELL LINE' named entity 'REGULATION' named entity 'ROS' named entity 'OXIDATIVE STRESS PATHWAY' named entity 'TRANSMEMBRANE POTENTIAL' named entity 'SUPPRESSING' named entity 'INDUCED' named entity 'INVESTIGATED' named entity 'REACTIVE OXYGEN SPECIES' named entity 'PATHOGENESIS' named entity 'INHIBITED' named entity 'APOPTOSIS' named entity 'PREVIOUS' named entity 'REDUCTION' named entity 'CASPASE-3 ACTIVATION' named entity 'KEY' named entity 'SCAVENGERS' named entity 'ACTIVATION OF P38 MAPK' named entity 'ADDITION' named entity 'P53' named entity 'COULD BE' named entity 'ROS ACCUMULATION' named entity 'BAX' covid:arg/faa567ed8f896e342be7b1a152ecec6843332b2d named entity 'ACTIVATED' named entity 'IRRADIATED' named entity 'ROLES' named entity 'INFECTION INDUCED' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'RELEASE' named entity 'ENTEROPATHOGENIC' named entity 'APOPTOTIC SIGNALING' named entity 'LETHAL' named entity 'THESE' named entity 'CORONAVIRUS' named entity 'WATERY DIARRHEA' named entity 'STUDIES' named entity 'REDISTRIBUTION' named entity 'CELL' named entity 'ELEMENT' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'APOPTOTIC SIGNALING' named entity 'ROS' named entity 'BCL-2' named entity 'OCCURRENCE' named entity 'SUGGEST' named entity 'BLOCKED' named entity 'CYTOCHROME C' named entity 'SEVERE' named entity 'STUDY' named entity 'RESULTS' named entity 'CAUSES' named entity 'N-ACETYL-L-CYSTEINE' named entity 'LOWERED' named entity 'DID' named entity 'PROMOTE' named entity 'ACTIVATED' named entity 'PK-15 CELL' named entity 'DEHYDRATION' named entity 'INFECTION' named entity 'HOST CELLS' named entity 'MITOCHONDRIAL' named entity 'The' named entity 'apoptosis' named entity 'cellular oxidation' named entity 'Caspase-3' named entity 'streptomycin' named entity 'Rockford, IL'

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