About: The Application of Genomics to Emerging Zoonotic Viral Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Application of Genomics to Emerging Zoonotic Viral Diseases
Creator	Osterhaus, Albert Andeweg, Arno Haagmans, Bart
source	Medline; PMC
abstract	Interspecies transmission of pathogens may result in the emergence of new infectious diseases in humans as well as in domestic and wild animals. Genomics tools such as high-throughput sequencing, mRNA expression profiling, and microarray-based analysis of single nucleotide polymorphisms are providing unprecedented ways to analyze the diversity of the genomes of emerging pathogens as well as the molecular basis of the host response to them. By comparing and contrasting the outcomes of an emerging infection with those of closely related pathogens in different but related host species, we can further delineate the various host pathways determining the outcome of zoonotic transmission and adaptation to the newly invaded species. The ultimate challenge is to link pathogen and host genomics data with biological outcomes of zoonotic transmission and to translate the integrated data into novel intervention strategies that eventually will allow the effective control of newly emerging infectious diseases.
has issue date	2009-10-26(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1000557
bibo:pmid	19855817
has license	cc-by
sha1sum (hex)	faced14dbb3af799525a67f97bd6d5b904a365e3
schema:url	https://doi.org/10.1371/journal.ppat.1000557
resource representing a document's title	The Application of Genomics to Emerging Zoonotic Viral Diseases
has PubMed Central identifier	PMC2734983
has PubMed identifier	19855817
schema:publication	PLoS Pathog
resource representing a document's body	covid:faced14dbb3af799525a67f97bd6d5b904a365e3#body_text
is schema:about of	named entity 'VIRAL DISEASES' named entity 'ZOONOTIC' named entity 'GENOMICS' named entity 'APPLICATION' named entity 'PATHOGENS' named entity 'TRANSMISSION' named entity 'transmission' named entity 'Genomics' named entity 'Application' named entity 'infection' named entity 'pathogens' named entity 'future research' named entity 'H5N1' named entity 'sialic acid' named entity 'epidemic' named entity 'SARS-CoV' named entity 'pathogens' named entity 'virus' named entity 'lentiviruses' named entity 'pneumonia' named entity 'IL-8' named entity 'Influenza' named entity 'genetically engineered' named entity 'genomes' named entity 'infection' named entity 'monkeypox virus' named entity 'antigenic' named entity 'SARS-CoV' named entity 'chemokines' named entity 'bioavailability' named entity 'innate immune response' named entity 'Orthomyxoviridae' named entity 'avian influenza' named entity 'pathogens' named entity 'immune genes' named entity 'HIV-1 and HIV-2' named entity 'cytokine' named entity 'interferon' named entity 'viral infections' named entity 'fever' named entity 'viral titers' named entity 'pathogen' named entity 'infection' named entity 'interferon' named entity 'host species' named entity 'high-throughput sequencing' named entity 'live animal markets' named entity 'microarray technology' named entity 'hemagglutinin' named entity 'influenza' named entity 'cell types' named entity 'viral replication' named entity 'host response' named entity 'infection' named entity 'genetic variation' named entity 'influenza viruses' named entity 'genome expression' named entity 'World War I' named entity 'human species' named entity 'binding affinity' named entity 'ACE2' named entity 'phylogenetic' named entity 'SARS-CoV' named entity 'SIV' named entity 'transcriptome' named entity 'interact' named entity 'viruses' named entity 'pathogens' named entity 'host evasion' named entity 'influenza' named entity 'viruses' named entity 'virus' named entity 'HIV-1' named entity 'infection' named entity 'interferon-regulated genes' named entity 'species barrier' named entity 'gene' named entity 'primate' named entity 'CXCL10'

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