About: A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs

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About: A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs
Creator	Alessio, Enrico Buson, Lisa Cagnin, Stefano Chemello, Francesco Severino Bonadio, Raphael
Source	PMC
abstract	In late 2012 it was evidenced that most of the human genome is transcribed but only a small percentage of the transcripts are translated. This observation supported the importance of non-coding RNAs and it was confirmed in several organisms. The most abundant non-translated transcripts are long non-coding RNAs (lncRNAs). In contrast to protein-coding RNAs, they show a more cell-specific expression. To understand the function of lncRNAs, it is fundamental to investigate in which cells they are preferentially expressed and to detect their subcellular localization. Recent improvements of techniques that localize single RNA molecules in tissues like single-cell RNA sequencing and fluorescence amplification methods have given a considerable boost in the knowledge of the lncRNA functions. In recent years, single-cell transcription variability was associated with non-coding RNA expression, revealing this class of RNAs as important transcripts in the cell lineage specification. The purpose of this review is to collect updated information about lncRNA classification and new findings on their function derived from single-cell analysis. We also retained useful for all researchers to describe the methods available for single-cell analysis and the databases collecting single-cell and lncRNA data. Tables are included to schematize, describe, and compare exposed concepts.
has issue date	2020-01-01(xsd:dateTime)
bibo:doi	10.3390/ijms21010302
bibo:pmid	31906285
has license	cc-by
sha1sum (hex)	fadd90c71b61efc6c47a0117d160ca9c77a914ec
schema:url	https://doi.org/10.3390/ijms21010302
resource representing a document's title	A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs
has PubMed Central identifier	PMC6982300
has PubMed identifier	31906285
schema:publication	Int J Mol Sci
resource representing a document's body	covid:fadd90c71b61efc6c47a0117d160ca9c77a914ec#body_text
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