About: Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice

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About: Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice
Creator	King, Chwan-Chuen Chang, Hsin-Hou Sun, Der-Shan Lien, Te-Sheng Su, Mei-Tzu Chen, Yen-Hsu Lin, Chun-Yu Chen, Tai-Hung Chiu, Yu-Hsiang Huang, Chung-Hao Li, Chen-Ru Lu, Chun-Chi Tsai, Chung-Lin
source	PMC
abstract	Dengue virus (DENV) infections may cause life-threatening dengue hemorrhagic fever (DHF). Suppressed protective immunity was shown in these patients. Although several hypotheses have been formulated, the mechanism of DENV-induced immunosuppression remains unclear. Previously, we found that cross-reactive antibodies against tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 1 (death receptor 4 [DR4]) were elicited in DHF patients, and that anti-DR4 autoantibody fractions were elicited by nonstructural protein 1 (NS1) immunizations in experimental mice. In this study, we found that anti-DR4 antibodies could suppress B lymphocyte function in vitro and in vivo. Treatment with the anti-DR4 immunoglobulin (Ig) induced caspase-dependent cell death in immortalized B lymphocyte Raji cells in vitro. Anti-DR4 Igs elicited by NS1 and DR4 immunizations markedly suppressed mouse spleen transitional T2 B (IgM(+)IgD(+)), bone marrow pre-pro-B (B220(+)CD43(+)), pre-B (B220(+)CD43(−)), and mature B cell (B220(+)IgD(+)) subsets in mice. Furthermore, functional analysis revealed that the pre-elicitation of anti-NS1 and anti-DR4 Ig titers suppressed subsequently neutralizing antibody production by immunization with DENV envelop protein. Our data suggest that the elicitation of anti-DR4 titers through DENV NS1 immunization plays a suppressive role in humoral immunity in mice.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1038/s41598-020-62958-0
bibo:pmid	32286343
has license	cc-by
sha1sum (hex)	fae230ce5b1886b977830bb4c4d4522bb5e38b30
schema:url	https://doi.org/10.1038/s41598-020-62958-0
resource representing a document's title	Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice
has PubMed Central identifier	PMC7156414
has PubMed identifier	32286343
schema:publication	Sci Rep
resource representing a document's body	covid:fae230ce5b1886b977830bb4c4d4522bb5e38b30#body_text
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