About: The recent increase of immunopeptidomic data, obtained by mass spectrometry (MS) or binding assays, opens unprecedented possibilities for investigating endogenous antigen presentation by the highly polymorphic human leukocyte antigen class I (HLA-I) protein. We introduce a flexible and easily interpretable peptide presentation prediction method. We validate its performance as a predictor of cancer neoantigens and viral epitopes and use it to reconstruct peptide motifs presented on specific HLA-I molecules.   Goto Sponge  NotDistinct  Permalink

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  • The recent increase of immunopeptidomic data, obtained by mass spectrometry (MS) or binding assays, opens unprecedented possibilities for investigating endogenous antigen presentation by the highly polymorphic human leukocyte antigen class I (HLA-I) protein. We introduce a flexible and easily interpretable peptide presentation prediction method. We validate its performance as a predictor of cancer neoantigens and viral epitopes and use it to reconstruct peptide motifs presented on specific HLA-I molecules.
Subject
  • Immune system
  • Transfusion medicine
  • Blood antigen systems
  • Gene complexes
  • Genes on human chromosome 6
  • Human MHC haplogroups
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