About: Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1
Creator	Cao, Zhijian Li, Wenxin Wu, Yingliang Song, Yu Han, Shisong Hong, Wei Li, Tian Zeng, Zhengyang Zhang, Runhong Zhang, Xianzheng
Source	Elsevier; Medline; PMC
abstract	Abstract Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen that causes severe diseases, but there are not effective and safe drugs in clinical therapy besides acyclovir (ACV) and related nucleoside analogs. In this study, two new venom peptides from the scorpion Heterometrus petersii were identified with effective inhibitory effect on HSV-1 infection in vitro. Both Hp1036 and Hp1239 peptides exhibited potent virucidal activities against HSV-1 (EC50 =0.43±0.09 and 0.41±0.06μM, respectively) and effective inhibitory effects when added at the viral attachment (EC50 =2.87±0.16 and 5.73±0.61μM, respectively), entry (EC50 =4.29±0.35 and 4.32±0.47μM, respectively) and postentry (EC50 =7.86±0.80 and 8.41±0.73μM, respectively) steps. Both Hp1036 and Hp1239 peptides adopted α-helix structure in approximate membrane environment and resulted in the destruction of the viral morphology. Moreover, Hp1036 and Hp1239 peptides entered Vero cells and reduced the intracellular viral infectivity. Taken together, Hp1036 and Hp1239 peptides are two anti-viral peptides with effective inhibitory effect on multiple steps of HSV-1 life cycle and therefore are good candidate for development as virucides.
has issue date	2014-02-28(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2013.11.013
bibo:pmid	24315793
has license	els-covid
sha1sum (hex)	fb052745e1e182f108e842cc14c2349c697197e1
schema:url	https://doi.org/10.1016/j.antiviral.2013.11.013
resource representing a document's title	Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1
has PubMed Central identifier	PMC7113736
has PubMed identifier	24315793
schema:publication	Antiviral Research
resource representing a document's body	covid:fb052745e1e182f108e842cc14c2349c697197e1#body_text
is schema:about of	named entity 'peptides' named entity 'approximate' named entity 'virucidal' named entity 'PEPTIDES' named entity 'ENTRY' named entity 'HSV-1' named entity 'TAKEN' named entity 'IS A' named entity 'CLINICAL' named entity 'VENOM' named entity 'VERO CELLS' named entity 'HERPES SIMPLEX VIRUS TYPE 1' named entity 'IN VITRO' named entity 'IDENTIFIED' named entity 'ACYCLOVIR' named entity 'EFFECTS' named entity 'STEPS' named entity 'MORPHOLOGY' named entity 'PEPTIDES' named entity 'HELIX STRUCTURE' named entity 'NEW' named entity 'EFFECTIVE' named entity 'INHIBITORY ACTIVITY' named entity 'MECHANISM' named entity 'HETEROMETRUS PETERSII' named entity 'STUDY' named entity 'LIFE CYCLE' named entity 'SAFE' named entity 'A-HELIX' named entity 'INHIBITORY' named entity 'DEVELOPMENT' named entity 'REDUCED' named entity '0.16' named entity 'DESTRUCTION' named entity 'GOOD' named entity 'WIDESPREAD' named entity 'CANDIDATE' named entity 'BUT' named entity 'MULTIPLE' named entity 'ENVIRONMENT' named entity '4.32' named entity 'SEVERE' named entity 'PATHOGEN' named entity 'HERPES SIMPLEX VIRUS TYPE 1' named entity 'INHIBITORY EFFECT' named entity 'SCORPION' named entity 'SCORPION VENOM' named entity 'ENTERED' named entity 'DISEASES' named entity 'DRUGS' named entity 'THERAPY' named entity 'HUMAN' named entity 'VIRAL' named entity 'ADDED' named entity 'MEMBRANE' named entity 'INFECTIVITY' named entity 'ADOPTED' named entity 'INTRACELLULAR' named entity '0.35' named entity '0.09' named entity 'VIRAL ATTACHMENT' named entity 'APPROXIMATE' named entity 'CAUSES' named entity '0.06' named entity 'NUCLEOSIDE ANALOGS' named entity 'HSV-1 INFECTION' named entity 'RELATED' named entity 'ACTIVITIES' covid:arg/fb052745e1e182f108e842cc14c2349c697197e1 named entity 'HSV-1' named entity 'effective' named entity 'good'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software