About: Serology characteristics of SARS-CoV-2 infection since exposure and post symptom onset

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serology characteristics of SARS-CoV-2 infection since exposure and post symptom onset
Creator	Zhang, Jun Chen, Yu Liu, Wei Yu, Fei Fan, Jian Yuan, Quan Li, Ting-Ting Affiliations, Li, Zhi-Yong Ge, Shengxiang Ge, Sheng-Xiang Hong, Cong-Ming Hou, Wang-Heng Li, Ting-Dong Lin, Sha Lou, Bin Su, Ying-Ying Wu, Ding-Hui Xia, Ning-Shao Yao, Xiang-Yang Zhang, Shi-Yin Zhang, Xue-Jie Zhang, Ya-Li Zheng, Shu-Fa Zhou, Guo-Liang Zou, Qian-Da
source	Medline; PMC
abstract	BACKGROUND: Timely diagnosis of SARS-CoV-2 infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated. METHOD: Serial sera of 80 patients with PCR-confirmed COVID-19 were collected at the First Affiliated Hospital of Zhejiang University, China. Total antibody (Ab), IgM and IgG antibodies against SARS-CoV-2 were detected, and the antibody dynamics during the infection were described. RESULTS: The seroconversion rates for Ab, IgM and IgG were 98.8%, 93.8% and 93.8%, respectively. The first detectible serology marker was Ab, followed by IgM and IgG, with a median seroconversion time of 15, 18 and 20 days post exposure (d.p.e) or 9, 10 and 12 days post onset (d.p.o), respectively. The antibody levels increased rapidly beginning at 6 d.p.o. and were accompanied by a decline in viral load. For patients in the early stage of illness (0–7 d.p.o), Ab showed the highest sensitivity (64.1%) compared to IgM and IgG (33.3% for both, p<0.001). The sensitivities of Ab, IgM and IgG increased to 100%, 96.7% and 93.3% 2 weeks later, respectively. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays. CONCLUSIONS: A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic specific diagnosis and helpful information to evaluate the adapted immunity status of patients.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1183/13993003.00763-2020
bibo:pmid	32430429
has license	cc-by-nc
sha1sum (hex)	fb06b61cbd6bf279d06fb5cc4d88ad0bba083ea1
schema:url	https://doi.org/10.1183/13993003.00763-2020
resource representing a document's title	Serology characteristics of SARS-CoV-2 infection since exposure and post symptom onset
has PubMed Central identifier	PMC7401320
has PubMed identifier	32430429
schema:publication	Eur Respir J
resource representing a document's body	covid:fb06b61cbd6bf279d06fb5cc4d88ad0bba083ea1#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'test' named entity 'd.p.o.' named entity 'onset' named entity 'onset' named entity 'AFFILIATED' named entity 'METHOD' named entity 'IGM' named entity 'DESCRIBED' named entity 'TWO WEEKS' named entity 'PATIENTS' named entity 'ILLNESS' named entity 'VALUE' named entity 'ONSET' named entity 'antibody' named entity 'Timely' named entity 'tests' named entity 'Total' named entity 'SARS-CoV-2' named entity 'antibody' named entity 'SARS-CoV-2' named entity 'Results' named entity 'levels' named entity 'seroconversion' named entity 'Antibody' named entity 'IgG' named entity 'antibody' named entity 'IgG' named entity 'antibody test' named entity 'serology' named entity 'SARS-CoV-2' named entity 'IgG' named entity 'IgM' named entity 'PCR' named entity 'seroconversion' named entity 'Serology' named entity 'infection' named entity 'test' named entity 'median' named entity 'seroconversion' named entity 'Zhejiang University' named entity 'Antibody tests' named entity 'antibody' named entity 'Serology' named entity 'infection' named entity 'IgG' named entity 'infection' named entity 'serology' named entity 'complement' named entity 'infection' named entity 'IgG' named entity 'infection' named entity 'COVID-19' named entity 'infection' named entity 'SARS-CoV-2' named entity 'For'

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