About: Protein pI alteration related to strain variation of infectious bronchitis virus, an avian Coronavirus

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About: Protein pI alteration related to strain variation of infectious bronchitis virus, an avian Coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protein pI alteration related to strain variation of infectious bronchitis virus, an avian Coronavirus
Creator	Chang, Pei Sadasiv, E Sadasiv, Eileen Yeh, Tamson
Source	Elsevier; Medline; PMC
abstract	Abstract Viral proteins of two strains of infectious bronchitis virus (IBV), which have different tissue trophism and serology, were separated on the basis of their isoelectric points (pI). The viruses have four structural proteins; the protein of greatest serological importance is found at the peplomer tip. The viral structural proteins separated by isoelectric focusing were identified by comparison to SDS-PAGE separations. Three protein bands were identical in pI and one protein band showed a difference in pI between strains. When the renatured viral proteins were Western blotted and reacted with strain-specific antiserum, antigen-antibody complexing was seen only at points corresponding to the strain-specific variant bands. For IBV strain Mass-41, antigen-antibody complexing occurred at a pI of 6.8, and, for IBV strain Ark-99, at 7.2. No cross reaction of antisera was observed for either strain. Since tissue affinities are a function of the viral peplomer-mediated attachment of virus to cells and are often directly related to pathogenicity, it appears that altered pathogenicity of strains of IBV may be detected by alteration of pI of the proteins. Classification by pI of proteins of at least the smaller viruses allows untypeable, highly pathogenic or persistent strains of these viruses to be characterized on the basis of variant proteins.
has issue date	1991-06-30(xsd:dateTime)
bibo:doi	10.1016/0166-0934(91)90012-o
bibo:pmid	1658026
has license	els-covid
sha1sum (hex)	fb21d026092146fa953db2a33f6730a4648d11e7
schema:url	https://doi.org/10.1016/0166-0934%2891%2990012-o
resource representing a document's title	Protein pI alteration related to strain variation of infectious bronchitis virus, an avian Coronavirus
has PubMed Central identifier	PMC7119808
has PubMed identifier	1658026
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:fb21d026092146fa953db2a33f6730a4648d11e7#body_text
is schema:about of	named entity 'RELATED' named entity 'bands' named entity 'infectious bronchitis' named entity 'Coronavirus' named entity 'WESTERN' named entity 'ANTIBODY' named entity 'EITHER' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'VARIANT' named entity 'ANTIGEN' named entity 'MASS' named entity 'PROTEIN BAND' named entity 'BANDS' named entity 'FOUND' named entity 'ISOELECTRIC FOCUSING' named entity 'IDENTIFIED BY' named entity 'BASIS' named entity 'SEROLOGY' named entity 'CROSS REACTION' named entity 'ANTISERA' named entity '7.2' named entity 'PROTEIN ' named entity 'DIFFERENCE' named entity 'STRAIN' named entity 'STRUCTURAL PROTEINS' named entity 'OBSERVED' named entity 'POINTS' named entity 'ANTISERUM' named entity 'VARIATION' named entity 'VIRUSES' named entity 'IDENTICAL' named entity 'AVIAN CORONAVIRUS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'ALTERATION' named entity 'SEROLOGICAL' named entity 'ARK' named entity 'GREATEST' named entity 'SEPARATED' named entity 'THEIR' named entity 'TISSUE' named entity 'TIP' named entity 'DIFFERENT' named entity 'PROTEIN ' named entity 'SEEN' named entity 'VIRAL STRUCTURAL PROTEINS' named entity 'STRAIN' named entity 'SDS-PAGE' named entity 'HAVE' named entity 'VIRAL PROTEINS' named entity 'OCCURRED' named entity 'SPECIFIC' named entity 'COMPARISON' named entity 'STRAINS' covid:arg/fb21d026092146fa953db2a33f6730a4648d11e7 named entity 'protein' named entity 'antiserum' named entity 'strains' named entity 'proteins' named entity 'Western' named entity 'Protein' named entity 'infectious bronchitis virus' named entity 'viruses' named entity 'protein' named entity 'IBV' named entity 'serology' named entity 'avian Coronavirus' named entity 'bands' named entity 'electron microscopy' named entity '300 nm' named entity 'acrylamide' named entity 'glycosylated' named entity 'carbohydrate' named entity 'infection' named entity 'Gels' named entity 'viral structural proteins' named entity 'IBV' named entity '3.5' named entity 'antigenic'

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