About: Regulation of Immunogen Processing: Signal Sequences and Their Application for the New Generation of DNA-Vaccines

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About: Regulation of Immunogen Processing: Signal Sequences and Their Application for the New Generation of DNA-Vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of Immunogen Processing: Signal Sequences and Their Application for the New Generation of DNA-Vaccines
Creator	Isaguliants, M Karpov, V Starodubova, E
Source	Medline; PMC
abstract	Immunization with naked genes (DNA–immunization) is a perspective modern approach to prophylactic as well as therapeutic vaccination against pathogens, as well as cancer and allergy. A panel of DNA immunogens has been developed, some are already in the clinical trials. However, the immunogenicity of DNA vaccines, specifically of those applied to humans, needs a considerable improvement. There are several approaches to increase DNA vaccine immunogenicity. One approach implies the modifications of the encoded immunogen that change its processing and presentation, and thus the overall pattern of anti–immunogen response. For this, eukaryotic expression vectors are constructed that encode the chimeric proteins composed of the immunogen and specialized targeting or signal sequences. The review describes a number of signals that if fused to immunogen, target it into the predefined subcellular compartments. The review gives examples of their application for DNA–immunization.
has issue date	2010-04-01(xsd:dateTime)
bibo:pmid	22649628
has license	cc-by
sha1sum (hex)	fb24be7627ebce76ab2862e689432a8a0de11343
resource representing a document's title	Regulation of Immunogen Processing: Signal Sequences and Their Application for the New Generation of DNA-Vaccines
has PubMed Central identifier	PMC3347541
has PubMed identifier	22649628
schema:publication	Acta Naturae
resource representing a document's body	covid:fb24be7627ebce76ab2862e689432a8a0de11343#body_text
is schema:about of	named entity 'allergy' named entity 'encode' named entity 'encoded' named entity 'eukaryotic' named entity 'NEW' named entity 'THEIR' named entity 'APPLICATION' named entity 'IMPROVEMENT' named entity 'REGULATION' named entity 'DNA' named entity 'NEEDS' named entity 'PATTERN' named entity 'APPROACHES' named entity 'CLINICAL TRIALS' named entity 'HUMANS' named entity 'CHIMERIC PROTEINS' named entity 'APPLIED' named entity 'GENERATION' named entity 'DNA' named entity 'ITS' named entity 'IMMUNOGEN' named entity 'VACCINES' named entity 'SEQUENCES' named entity 'IS A' named entity 'CONSTRUCTED' named entity 'ENCODED' named entity 'ALLERGY' named entity 'EUKARYOTIC' named entity 'TARGETING' named entity 'VACCINATION' named entity 'IMMUNOGENS' named entity 'PROCESSING' named entity 'CHANGE' named entity 'APPROACH' named entity 'PRESENTATION' named entity 'PANEL' named entity 'ENCODE' named entity 'CANCER' named entity 'EXPRESSION VECTORS' named entity 'SPECIALIZED' named entity 'SIGNAL' named entity 'CONSIDERABLE' named entity 'PROPHYLACTIC' named entity 'GENES' named entity 'NAKED' named entity 'IMMUNIZATION' named entity 'PATHOGENS' named entity 'THERAPEUTIC' named entity 'OVERALL' named entity 'DNA VACCINE' named entity 'TO INCREASE' named entity 'RESPONSE' named entity 'IMMUNOGEN' named entity 'COMPOSED OF' named entity 'IMMUNOGENICITY' named entity 'PROCESSING' named entity 'SIGNAL' named entity 'PERSPECTIVE' named entity 'DNA VACCINES' named entity 'DNA vaccine' named entity 'therapeutic' named entity 'humans' named entity 'immunogen' named entity 'DNA vaccines' named entity 'genes' named entity 'immunogen' named entity 'immunogens' named entity 'allergy' named entity 'immunization' named entity 'clinical trials' named entity 'DNA vaccine' named entity 'immunization' named entity 'gene' named entity 'mice' named entity 'antibody response' named entity 'ubiquitin' named entity 'endogenous' named entity 'immunization' named entity 'therapeutic vaccines' named entity 'antigen' named entity 'immunization'

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