About: Tuberculosis mortality: patient characteristics and causes

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Tuberculosis mortality: patient characteristics and causes
Creator	Cheng, Wern-Cherng Wang, Jann-Yuan Chen, Jong-Min Hsu, Chia-Lin Kuo, Yao-Wen Lee, Li-Na Lin, Chou-Han Lin, Chou-Jui
source	PMC
abstract	BACKGROUND: In the antibiotic era, tuberculosis (TB) still causes a substantial number of mortalities. We aimed to identify the causes and risks of death among TB patients. METHODS: Medical records of mortality cases of culture-proven TB diagnosed during 2003–2007 were reviewed. All TB deaths were classified into 2 groups (TB-related and non-TB-related), based on the underlying cause of death. RESULTS: During the study period, 2016 cases (male: 71.1%) of culture-proven TB were identified. The mean age was 59.3 (range: 0.3–96) years. The overall mortality rate was 12.3% (249 cases) and the mean age at death was 74 years; 17.3% (43 cases) of all TB deaths were TB-related. Most of the TB-related deaths occurred early (median survival: 20 days), and the patient died of septic shock. Malignancy, liver cirrhosis, renal failure, and miliary and pneumonic radiographic patterns were all independent predictors for all TB deaths. Cavitary, miliary and pneumonic radiographic patterns were all significant predictive factors for TB-related death. Extrapulmonary involvement and liver cirrhosis were also factors contributing to TB-related death. CONCLUSIONS: The majority of TB deaths were ascribed to non-TB-related causes. Managing TB as well as underlying comorbidities in a multidisciplinary approach is essential to improve the outcome of patients in an aging population. However, the clinical manifestations of patients with TB-related death vary; many progressed to fulminant septic shock requiring timely recognition with prompt treatment to prevent early death.
has issue date	2014-01-03(xsd:dateTime)
bibo:doi	10.1186/1471-2334-14-5
bibo:pmid	24387757
has license	cc-by
sha1sum (hex)	fb553f0b443bbf57dd5ae7ba30d97652e2ebdaa5
schema:url	https://doi.org/10.1186/1471-2334-14-5
resource representing a document's title	Tuberculosis mortality: patient characteristics and causes
has PubMed Central identifier	PMC3890594
has PubMed identifier	24387757
schema:publication	BMC Infect Dis
resource representing a document's body	covid:fb553f0b443bbf57dd5ae7ba30d97652e2ebdaa5#body_text
is schema:about of	named entity 'substantial' named entity 'patient' named entity 'BACKGROUND' named entity 'RISKS' named entity 'antibiotic' named entity 'Taiwan' named entity 'radiographic' named entity 'ALI' named entity 'HIV/AIDS' named entity 'isoniazid' named entity 'pre-hospital' named entity 'MDRTB' named entity 'Chicago' named entity 'TB treatment' named entity 'National Taiwan University Hospital' named entity 'TB treatment' named entity 'Russia' named entity 'pneumonic' named entity 'coinfection' named entity 'thoracentesis' named entity 'rifampicin' named entity 'culture results' named entity 'death certificates' named entity 'case-fatality rates' named entity 'risk factor' named entity 'Statistical analysis' named entity 'aseptically' named entity 'Taiwan' named entity 'malignancy' named entity 'ARDS' named entity 'confounding' named entity 'older patients' named entity 'control group' named entity 'WHO' named entity 'hypoxemic' named entity 'ARDS' named entity 'miliary' named entity 'Australia' named entity 'pneumonic' named entity 'infection' named entity 'miliary' named entity 'liver disease' named entity 'respiratory failure' named entity 'acute respiratory distress syndrome' named entity 'sepsis' named entity 'human immunodeficiency virus' named entity 'urine' named entity 'sepsis' named entity 'Russia' named entity 'diabetes mellitus' named entity 'differential diagnoses' named entity 'risk factor' named entity 'MDRTB' named entity 'HIV' named entity 'all-cause mortality' named entity 'case fatality rate' named entity 'infection' named entity 'Canada' named entity 'case-control studies' named entity 'postmortem' named entity 'miliary' named entity 'autopsy' named entity 'MDRTB' named entity 'malignancy' named entity 'miliary' named entity 'North America' named entity 'chemotherapy' named entity 'sepsis' named entity 'medical records' named entity 'mortality rate' named entity 'lipoarabinomannan' named entity 'standard deviation' named entity 'fluid resuscitation' named entity 'bacilli'

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