About: The broad-spectrum antiviral functions of IFIT and IFITM proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The broad-spectrum antiviral functions of IFIT and IFITM proteins
Creator	Farzan, Michael Diamond, Michael Louis, St Ave, S
Source	Medline; PMC
abstract	Over the past few years, several groups have identified novel genes downstream of type I interferon (IFN) signaling that inhibit infection by individual or multiple families of viruses. Among these IFN stimulated genes (ISGs) with antiviral activity are two genetically and functionally distinct families — IFN-induced proteins with tetratricopeptide repeats (IFIT) and IFN-induced transmembrane proteins (IFITM). This review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM genes, which explain their broad-spectrum activity against replication, spread, and disease pathogenesis of a range of human viruses.
has issue date	2012-12-14(xsd:dateTime)
bibo:doi	10.1038/nri3344
bibo:pmid	23237964
has license	green-oa
sha1sum (hex)	fb9006ed6379f4b0712537d159bb23aa1fe6b6a3
schema:url	https://doi.org/10.1038/nri3344
resource representing a document's title	The broad-spectrum antiviral functions of IFIT and IFITM proteins
has PubMed Central identifier	PMC3773942
has PubMed identifier	23237964
schema:publication	Nature Reviews Immunology
resource representing a document's body	covid:fb9006ed6379f4b0712537d159bb23aa1fe6b6a3#body_text
is schema:about of	named entity 'PUBLIC' named entity 'BROAD' named entity 'genetically' named entity 'proteins' named entity 'antiviral' named entity 'IFIT' named entity 'UNIQUE' named entity 'ACTIVITY' named entity 'STIMULATED' named entity 'NOVEL' named entity 'IDENTIFIED' named entity 'HAVE' named entity 'MULTIPLE' named entity 'ACTION' named entity 'INTERFERON ' named entity 'YEARS' named entity 'VIRUSES' named entity 'MODULATION' named entity 'IFN' named entity 'THEIR' named entity 'IFIT' named entity 'NIH' named entity 'MANUSCRIPT' named entity 'PROTEINS' named entity 'INDIVIDUAL' named entity 'PAST' named entity 'GENES' named entity 'RANGE' named entity 'PROTEINS' named entity 'IDENTIFYING' named entity 'HUMAN' named entity 'REVIEW' named entity 'MECHANISMS' named entity 'RECENT' named entity 'INFECTION' named entity 'TYPE I INTERFERON' named entity 'GROUPS' named entity 'SPREAD' named entity 'SPECTRUM' named entity 'ANTIVIRAL' named entity 'TRANSMEMBRANE PROTEINS' named entity 'INDUCED' named entity 'DOWNSTREAM' named entity 'FAMILIES' named entity 'SIGNALING' named entity 'DISTINCT' named entity 'DISEASE' named entity 'PATHOGENESIS' named entity 'INFLAMMATORY RESPONSES' named entity 'ANTIVIRAL ACTIVITY' named entity 'REPEATS' named entity 'REPLICATION' named entity 'THESE' named entity 'FUNCTIONS' named entity 'AUTHOR' named entity 'ACCESS' covid:arg/fb9006ed6379f4b0712537d159bb23aa1fe6b6a3 named entity 'multiple' named entity 'mechanisms' named entity 'proteins' named entity 'IFITM1' named entity 'IFN' named entity 'type I IFN' named entity 'myeloid cells' named entity 'plasma membrane' named entity 'locus' named entity 'pseudotyped' named entity 'STAT1' named entity 'murine' named entity 'viruses' named entity 'transmembrane proteins' named entity 'protein' named entity 'RNA' named entity 'viruses' named entity 'TPR' named entity 'Biochemical studies' named entity 'protein expression' named entity 'cytoplasm'

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