About: Tollip or Not Tollip: What Are the Evolving Questions behind It?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tollip or Not Tollip: What Are the Evolving Questions behind It?
Creator	Li, Liwu Antô, Malcom Bonetti, Ana Brandeburgo, Manfredi Jú, Santos Lio Dias, Cé Prudencio Luiz, Denis
Source	PMC
abstract	Tollip plays an important role in the interleukin-1 receptor IL-1R and Toll pathways. As a modulator of the immune pathway, it indirectly controls the amount of antimicrobial peptides. This could indicate a vital step in maintaining animal immune systems and preventing infection. Evolutionary questions are crucial to understanding the conservation and functioning of the biochemical pathways like the Tollip-mediated one. Through an analysis of 36 sequences of the Tollip protein from different animal taxa, downloaded from Kyoto Encyclopedia of Genes and Genomes (KEGG) databank, we inferred diverse evolutionary parameters, such as molecular selection and structure conservation, by analyzing residue by residue, beyond the canonical parameters to this type of study, as maximum likelihood trees. We found that Tollip presented different trends in its evolving history. In primates, the protein is becoming more unstable, just the opposite is observed in the arthropod group. The most interesting finding was the concentration of positively selected residues at amino terminal ends. Some observed topological incongruences in maximum likelihood trees of complete and curated Tollip data sets could be explained through horizontal transfers, evidenced by recombination detection. These results suggest that there is more to be researched and understood about this protein.
has issue date	2014-05-14(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0097219
bibo:pmid	24828816
has license	cc-by
sha1sum (hex)	fb9b75c5e290a5ff3b49c2f0f93e05a1dcff78df
schema:url	https://doi.org/10.1371/journal.pone.0097219
resource representing a document's title	Tollip or Not Tollip: What Are the Evolving Questions behind It?
has PubMed Central identifier	PMC4020778
has PubMed identifier	24828816
schema:publication	PLoS One
resource representing a document's body	covid:fb9b75c5e290a5ff3b49c2f0f93e05a1dcff78df#body_text
is schema:about of	named entity 'data sets' named entity 'amino terminal' named entity 'concentration' named entity 'topological' named entity 'Questions' named entity 'Are' named entity 'TOLLIP' covid:arg/fb9b75c5e290a5ff3b49c2f0f93e05a1dcff78df named entity 'UNDERSTOOD' named entity 'TOLLIP' named entity 'BEYOND' named entity 'ANALYSIS' named entity 'SEQUENCES' named entity 'RESULTS' named entity 'ANIMAL' named entity 'RECOMBINATION DETECTION' named entity 'SELECTION' named entity 'EXPLAINED' named entity 'LIKE' named entity 'FINDING' named entity 'CURATED' named entity 'MODULATOR' named entity 'PRESENTED' named entity 'ABOUT' named entity 'TYPE OF STUDY' named entity 'TOLL' named entity 'GROUP' named entity 'PATHWAYS' named entity 'IMMUNE SYSTEMS' named entity 'PARAMETERS' named entity 'ROLE' named entity 'STEP' named entity 'HISTORY' named entity 'AMINO TERMINAL' named entity 'PEPTIDES' named entity 'COULD BE' named entity 'MOLECULAR' named entity 'STRUCTURE' named entity 'ENDS' named entity 'UNSTABLE' named entity 'DIFFERENT' named entity 'THESE' named entity 'ARTHROPOD' named entity 'TRANSFERS' named entity 'ITS' named entity 'TREES' named entity 'ANALYZING' named entity 'COMPLETE' named entity 'FUNCTIONING' named entity 'EVOLVING' named entity 'INTERLEUKIN-1 RECEPTOR' named entity 'HORIZONTAL' named entity 'MEDIATED' named entity 'TRENDS' named entity 'PRIMATES' named entity 'PROTEIN ' named entity 'WHAT' named entity 'MAINTAINING' named entity 'IL-1R' named entity 'IMMUNE' named entity 'IMPORTANT' named entity 'CONCENTRATION OF' named entity 'DATA SETS' named entity 'MAXIMUM LIKELIHOOD' named entity 'PREVENTING' named entity 'UNDERSTANDING' named entity 'DIVERSE' named entity 'PROTEIN' named entity 'FOUND' named entity 'CONSERVATION' named entity 'JUST' named entity 'INTERESTING' named entity 'INFERRED' named entity 'KYOTO ENCYCLOPEDIA OF GENES AND GENOMES' named entity 'TAXA'

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