About: Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations

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About: Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations
Creator	Steinmann, Eike Todt, Daniel Walter, Stephanie Brown, Richard
Source	Medline; PMC
abstract	Hepatitis E virus (HEV), an important agent of viral hepatitis worldwide, can cause severe courses of infection in pregnant women and immunosuppressed patients. To date, HEV infections can only be treated with ribavirin (RBV). Major drawbacks of this therapy are that RBV is not approved for administration to pregnant women and that the virus can acquire mutations, which render the intra-host population less sensitive or even resistant to RBV. One of the proposed modes of action of RBV is a direct mutagenic effect on viral genomes, inducing mismatches and subsequent nucleotide substitutions. These transition events can drive the already error-prone viral replication beyond an error threshold, causing viral population extinction. In contrast, the expanded heterogeneous viral population can facilitate selection of mutant viruses with enhanced replication fitness. Emergence of these mutant viruses can lead to therapeutic failure. Consequently, the onset of RBV treatment in chronically HEV-infected individuals can result in two divergent outcomes: viral extinction versus selection of fitness-enhanced viruses. Following an overview of RNA viruses treated with RBV in clinics and a summary of the different antiviral modes of action of this drug, we focus on the mutagenic effect of RBV on HEV intrahost populations, and how HEV is able to overcome lethal mutagenesis.
has issue date	2016-10-13(xsd:dateTime)
bibo:doi	10.3390/v8100283
bibo:pmid	27754363
has license	cc-by
sha1sum (hex)	fba08f3ce8a1335d06623126e44863cf1e73a509
schema:url	https://doi.org/10.3390/v8100283
resource representing a document's title	Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations
has PubMed Central identifier	PMC5086615
has PubMed identifier	27754363
schema:publication	Viruses
resource representing a document's body	covid:fba08f3ce8a1335d06623126e44863cf1e73a509#body_text
is schema:about of	named entity 'population' named entity 'mutagenic' named entity 'population' named entity 'infections' named entity 'RBV' named entity 'mutagenic' named entity 'treated' named entity 'Mutations' named entity 'EXTINCTION' named entity 'LEAD' named entity 'RESULT' named entity 'MAJOR' named entity 'MUTATIONS' named entity 'ENHANCED' named entity 'INTRA' named entity 'VIRAL' named entity 'CONTRAST' named entity 'HETEROGENEOUS' named entity 'SUMMARY' named entity 'COURSES' named entity 'ONE OF' named entity 'THERAPY' named entity 'TREATMENT' named entity 'THERAPEUTIC' named entity 'OVERVIEW' named entity 'HEV' named entity 'VIRAL' named entity 'RNA VIRUSES' named entity 'DRUG' named entity 'EMERGENCE' named entity 'MUTAGENIC EFFECT' named entity 'VIRUS' named entity 'PREGNANT WOMEN' named entity 'SENSITIVE' named entity 'INFECTION' named entity 'INFECTED' named entity 'MUTANT' named entity 'AGENT' named entity 'FOCUS' named entity 'VIRUSES' named entity 'VIRAL HEPATITIS' named entity 'DRIVE' named entity 'FOLLOWING' named entity 'GENOMES' named entity 'TREATED WITH' named entity 'SEVERE' named entity 'CHRONICALLY' named entity 'WORLDWIDE' named entity 'FAILURE' named entity 'SUBSEQUENT' named entity 'OUTCOMES' named entity 'CLINICS' named entity 'EVENTS' named entity 'EXPANDED ' named entity 'INDIVIDUALS' named entity 'FITNESS' named entity 'POPULATION EXTINCTION' named entity 'NUCLEOTIDE' named entity 'IMPORTANT' named entity 'EXTINCTION' named entity 'RESISTANT TO' named entity 'DATE' named entity 'RENDER' named entity 'SELECTION' named entity 'VIRAL REPLICATION' named entity 'ENHANCING' named entity 'ERROR' named entity 'CAUSE' named entity 'MUTATIONS' named entity 'HEPATITIS E VIRUS' named entity 'FITNESS' named entity 'MUTAGENIC' named entity 'EFFECTS' named entity 'OVERCOME' named entity 'SELECTION' named entity 'HOST POPULATION' named entity 'CAUSING' named entity 'PRONE'

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