About: A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 Serotype

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About: A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 Serotype Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 Serotype
Creator	Cavanagh, David Britton, Paul Armesto, Maria Thiel, Volker Abu-Median, Abu-Bakr Evans, Sharon Keep, Sarah Gallen, St Hospital, Kantonal
Source	Medline; PMC
abstract	We have shown previously that replacement of the spike (S) gene of the apathogenic IBV strain Beau-R with that from the pathogenic strain of the same serotype, M41, resulted in an apathogenic virus, BeauR-M41(S), that conferred protection against challenge with M41 [1]. We have constructed a recombinant IBV, BeauR-4/91(S), with the genetic backbone of Beau-R but expressing the spike protein of the pathogenic IBV strain 4/91(UK), which belongs to a different serogroup as Beaudette or M41. Similar to our previous findings with BeauR-M41(S), clinical signs observations showed that the S gene of the pathogenic 4/91 virus did not confer pathogenicity to the rIBV BeauR-4/91(S). Furthermore, protection studies showed there was homologous protection; BeauR-4/91(S) conferred protection against challenge with wild type 4/91 virus as shown by the absence of clinical signs, IBV RNA assessed by qRT-PCR and the fact that no virus was isolated from tracheas removed from birds primarily infected with BeauR-4/91(S) and challenged with IBV 4/91(UK). A degree of heterologous protection against M41 challenge was observed, albeit at a lower level. Our results confirm and extend our previous findings and conclusions that swapping of the ectodomain of the S protein is a precise and effective way of generating genetically defined candidate IBV vaccines.
has issue date	2011-08-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0024352
bibo:pmid	21912629
has license	cc-by
sha1sum (hex)	fbb13d5bcfe0597fc854533fa1637fd4c415bb5a
schema:url	https://doi.org/10.1371/journal.pone.0024352
resource representing a document's title	A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 Serotype
has PubMed Central identifier	PMC3166170
has PubMed identifier	21912629
schema:publication	PLoS One
resource representing a document's body	covid:fbb13d5bcfe0597fc854533fa1637fd4c415bb5a#body_text
is schema:about of	named entity 'backbone' named entity 'removed' named entity 'protein' named entity 'virus' named entity 'Heterologous' named entity 'VACCINES' named entity 'PRECISE' named entity 'GENE' named entity 'REMOVED' named entity 'EFFECTIVE' named entity 'QRT-PCR' named entity 'SEROTYPE' named entity 'DEFINED' named entity '28S' named entity 'PATHOGENIC' named entity 'BUT' named entity 'IS A' named entity 'LOWER' named entity 'EXTEND' named entity 'CONSTRUCTED' named entity 'WILD TYPE' named entity 'OBSERVATIONS' named entity 'S PROTEIN' named entity 'SPIKE' named entity 'LEVEL' named entity 'ABSENCE OF' named entity 'PROTEIN ' named entity 'SIMILAR' named entity 'VIRUS' named entity 'STUDIES' named entity 'IBV' named entity 'ISOLATED' named entity 'PREVIOUS FINDINGS' named entity 'REPLACEMENT' named entity 'GENE' named entity 'DID' named entity 'CONFIRM' named entity 'SPIKE PROTEIN' named entity 'OBSERVED' named entity 'CONCLUSIONS' covid:arg/fbb13d5bcfe0597fc854533fa1637fd4c415bb5a named entity 'BACKBONE' named entity 'RESULTS' named entity 'GENETIC' named entity 'HETEROLOGOUS' named entity 'SEROGROUP' named entity 'CANDIDATE' named entity 'HETEROLOGOUS' named entity 'SEROTYPE' named entity 'AVIAN INFECTIOUS BRONCHITIS VIRUS' named entity 'SPIKE' named entity 'RECOMBINANT' named entity 'BIRDS' named entity 'OUR' named entity 'DIFFERENT' named entity 'HOMOLOGOUS' named entity 'FACT' named entity 'PATHOGENICITY' named entity 'RNA' named entity 'CHALLENGE' named entity 'HAVE' named entity 'DEGREE' named entity 'TRACHEAS' named entity '5B1' named entity 'M41' named entity 'GENERATING' named entity 'WAY' named entity 'ASSESSED' named entity 'ECTODOMAIN' named entity 'BELONGING' named entity 'PREVIOUSLY' named entity 'INFECTED' named entity 'STRAIN'

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