About: Acute Exacerbation and Respiratory InfectionS in COPD (AERIS): protocol for a prospective, observational cohort study

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Acute Exacerbation and Respiratory InfectionS in COPD (AERIS): protocol for a prospective, observational cohort study
Creator	Aris, Emmanuel Barton, Anna Bourne, Simon Clarke, Stuart Cohet, Catherine Devaster, Jeanne-Marie Kim, Viktoriya Mesia-Vela, Sonia Tuck, Andy Wilkinson, Tom Ballou, W
source	Medline; PMC
abstract	INTRODUCTION: The aetiology of acute exacerbations of chronic obstructive pulmonary disease (COPD) remains incompletely understood and strategies for treatment and prevention have not altered significantly for many years. Improved understanding of the role of respiratory pathogens in acute exacerbations of COPD (AECOPD) is required and the use of molecular microbiological techniques may lead to insights into host–pathogen interactions and the development of more targeted therapeutic approaches. METHODS AND ANALYSES: Acute Exacerbation and Respiratory InfectionS in COPD (AERIS) is a longitudinal epidemiological study to assess how changes in the COPD airway microbiome contribute to the incidence and severity of AECOPD. Patients with COPD aged 40–85 are followed monthly for 2 years, and reviewed within 72 h of onset of symptoms of AECOPD. Exacerbations are detected using daily electronic diary cards. Blood, sputum, nasopharyngeal and urine samples are collected at prespecified timepoints. Molecular diagnostic and typing techniques are used to describe the dynamics of airway infection during AECOPD and stable disease, and associations with clinical outcome. This study aims to refine the case definition of AECOPD to reflect the possible microbiological aetiology. AERIS will assess the impact of AECOPD on health-related quality of life and healthcare resource utilisation, and the possible interactions between nutritional status, infection and immune responses. ETHICS AND DISSEMINATION: AERIS is conducted in accordance with the Declaration of Helsinki and Good Clinical Practice, and has been approved by the institutional ethics and review board. All participants must provide written informed consent. The results obtained will be disseminated at international medical conferences and in peer-reviewed publications. DISCUSSION: Few other studies have addressed the complexity of the microbiological and systemic components of COPD or employed real-time electronic tracking of symptoms to identify AECOPD and potential aetiological triggers. RESULTS: Results of AERIS will increase our understanding of the contribution of pathogens to AECOPD, potentially leading to new targeted therapeutic and preventative interventions. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT01360398.
has issue date	2014-03-07(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2013-004546
bibo:pmid	24607562
has license	cc-by-nc
sha1sum (hex)	fbb2b307ad6be9561286c3b8a9114d283fb2e224
schema:url	https://doi.org/10.1136/bmjopen-2013-004546
resource representing a document's title	Acute Exacerbation and Respiratory InfectionS in COPD (AERIS): protocol for a prospective, observational cohort study
has PubMed Central identifier	PMC3948575
has PubMed identifier	24607562
schema:publication	BMJ Open
resource representing a document's body	covid:fbb2b307ad6be9561286c3b8a9114d283fb2e224#body_text
is schema:about of	named entity 'IMPROVED' named entity 'INTRODUCTION' named entity 'STRATEGIES' named entity 'AETIOLOGY' named entity 'TARGETED' named entity 'YEARS' named entity 'RESPIRATORY PATHOGENS' named entity 'COPD' named entity 'ACUTE EXACERBATIONS' named entity 'observational' named entity 'TREATMENT' named entity 'PROTOCOL' named entity 'RESPIRATORY INFECTIONS' named entity 'MOLECULAR' named entity 'MICROBIOLOGICAL TECHNIQUES' named entity 'HOST-PATHOGEN INTERACTIONS' named entity 'ACUTE EXACERBATION' named entity 'OBSERVATIONAL' named entity 'COPD' named entity 'REQUIRED' named entity 'LEAD' named entity 'INSIGHTS' named entity 'DEVELOPMENT' named entity 'UNDERSTOOD' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'ROLE' named entity 'APPROACHES' named entity 'COHORT STUDY' named entity 'PROSPECTIVE' named entity 'USE OF' named entity 'UNDERSTANDING' named entity 'ALTERED' named entity 'PREVENTION' named entity 'THERAPEUTIC' named entity 'HAVE' named entity 'microbiological' named entity 'incompletely' named entity 'therapeutic' named entity 'respiratory' named entity 'acute exacerbations' named entity 'acute exacerbations of COPD' named entity 'aetiology' named entity 'microbiological techniques' named entity 'therapeutic approaches' named entity 'COPD' named entity 'cohort study' named entity 'Good Clinical Practice' named entity 'Novartis' named entity 'COPD' named entity 'aetiology' named entity 'drug abuse' named entity 'pulmonary rehabilitation' named entity 'airway infection' named entity 'culture techniques' named entity 'all-cause' named entity 'bacterial pathogens' named entity 'COPD' named entity 'incidence rate' named entity 'macrolide antibiotics' named entity 'functional status' named entity 'patient-reported' named entity 'pneumonia' named entity 'viruses' named entity 'incidence rate' named entity 'lung volumes' named entity 'follow-up' named entity 'EQ-5D' named entity 'sample size' named entity 'COPD' named entity 'morbidity' named entity 'Malnutrition'

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