About: Extensive multiplex PCR diagnostics reveal new insights into the epidemiology of viral respiratory infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Extensive multiplex PCR diagnostics reveal new insights into the epidemiology of viral respiratory infections
Creator	Murcia, P Gunson, R Mcmenamin, J Nickbakhsh, S Thorburn, F Von Wissmann, B
source	Medline; PMC
abstract	Viral respiratory infections continue to pose a major global healthcare burden. At the community level, the co-circulation of respiratory viruses is common and yet studies generally focus on single aetiologies. We conducted the first comprehensive epidemiological analysis to encompass all major respiratory viruses in a single population. Using extensive multiplex PCR diagnostic data generated by the largest NHS board in Scotland, we analysed 44230 patient episodes of respiratory illness that were simultaneously tested for 11 virus groups between 2005 and 2013, spanning the 2009 influenza A pandemic. We measured viral infection prevalence, described co-infections, and identified factors independently associated with viral infection using multivariable logistic regression. Our study provides baseline measures and reveals new insights that will direct future research into the epidemiological consequences of virus co-circulation. In particular, our study shows that (i) human coronavirus infections are more common during influenza seasons and in co-infections than previously recognized, (ii) factors associated with co-infection differ from those associated with viral infection overall, (iii) virus prevalence has increased over time especially in infants aged <1 year, and (iv) viral infection risk is greater in the post-2009 pandemic era, likely reflecting a widespread change in the viral population that warrants further investigation.
has issue date	2016-03-02(xsd:dateTime)
bibo:doi	10.1017/s0950268816000339
bibo:pmid	26931455
has license	no-cc
sha1sum (hex)	fbcfbff740d181c8a834425c8d2c3203800a22ad
schema:url	https://doi.org/10.1017/s0950268816000339
resource representing a document's title	Extensive multiplex PCR diagnostics reveal new insights into the epidemiology of viral respiratory infections
has PubMed Central identifier	PMC7113017
has PubMed identifier	26931455
schema:publication	Epidemiol Infect
resource representing a document's body	covid:fbcfbff740d181c8a834425c8d2c3203800a22ad#body_text
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