About: Antigenicity of the peplomer protein of infectious bronchitis virus

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About: Antigenicity of the peplomer protein of infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antigenicity of the peplomer protein of infectious bronchitis virus
Creator	Koch~, Ciuus Kusters, Johannes Lenstra, Johanwes Van Der Zeijst, Bernard
Source	Elsevier; Medline; PMC
abstract	Abstract To study the antigenic structure of the peplomer protein of the avian coronavirus infectious bronchitis virus, fragments from the peplomer gene were generated by restriction-enzyme cleavage or by limited DNase digestion and inserted in the Escherichia coli expression plasrnid pEX (Stanley and Luzio, 1984). The antigenicity of the expression products was tested using a number of polyclonal antisera and monoclonal antibodies. The polyclonal antisera recognized different sets of epitopes in the 1162-residue sequence. The N-terminal region of one of the two subunits, S2, was recognized by all polyclonal sera and by two monoclonal antibodies. This clearly immunodominant region contains at least two adjacent or overlapping epitopes, one of which has been localized within 18 residues. The epitopes found as antigenic pEX expression products do not coincide with the regions in the S1 subunit that have been found to contain hypervariable sequences. We suggest that these regions constitute conformation dependent neutralization epitopes that cannot be detected in the pEX system. The relevance of our finclings for vaccine development is discussed.
has issue date	1989-01-31(xsd:dateTime)
bibo:doi	10.1016/0161-5890(89)90014-x
bibo:pmid	2467199
has license	els-covid
sha1sum (hex)	fbe77b2a78477062a2b4a5d7101c94c97bf94d0b
schema:url	https://doi.org/10.1016/0161-5890%2889%2990014-x
resource representing a document's title	Antigenicity of the peplomer protein of infectious bronchitis virus
has PubMed Central identifier	PMC7133629
has PubMed identifier	2467199
schema:publication	Molecular Immunology
resource representing a document's body	covid:fbe77b2a78477062a2b4a5d7101c94c97bf94d0b#body_text
is schema:about of	named entity 'ANTIGENICITY' named entity 'expression' named entity 'epitopes' named entity 'EXPRESSION' named entity 'DIGESTION' named entity 'PROTEIN ' named entity 'OVERLAPPING' named entity 'PEX' named entity 'INSERTED' named entity 'LOCALIZED' named entity 'ENZYME' named entity 'SEQUENCE' named entity 'ANTISERA' named entity 'MONOCLONAL ANTIBODIES' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'PRODUCTS' named entity 'ESCHERICHIA COLI' named entity 'N-TERMINAL ' named entity 'DNASE' named entity 'GENERATED' named entity 'GENE' named entity 'CONTAINS' named entity 'RESTRICTION' named entity 'STUDY' named entity 'CLEAVAGE' named entity 'PLASMID' named entity 'DIFFERENT' named entity 'ANTIGENICITY' named entity 'FRAGMENTS' named entity 'SERA' named entity 'AVIAN CORONAVIRUS' named entity 'ONE OF' named entity 'NUMBER OF' named entity 'EPITOPES' named entity 'STRUCTURE' named entity 'REGION' named entity 'LIMITED' named entity 'ADJACENT' named entity 'RESIDUE' named entity 'TESTED' named entity 'USING' named entity 'PROTEIN ' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'POLYCLONAL' covid:arg/fbe77b2a78477062a2b4a5d7101c94c97bf94d0b named entity 'localized' named entity 'monoclonal antibodies' named entity 'residues' named entity 'plasmid' named entity 'sequence' named entity 'generated' named entity 'residue' named entity 'coronavirus' named entity 'epitopes' named entity 'immunodominant' named entity 'monoclonal antibodies' named entity 'epitopes' named entity 'peplomer' named entity 'antigenic' named entity 'protein' named entity 'epitopes' named entity 'infectious bronchitis virus' named entity 'PROTEIN' named entity 'restriction enzymes' named entity 'antigenic' named entity 'phenol' named entity 'sonicator' named entity 'MAb' named entity 'epitope' named entity 'EDTA' named entity 'intramuscular injection' named entity 'protein' named entity 'epitopes' named entity 'antiserum' named entity 'protein' named entity 'polyclonal' named entity 'peplomer' named entity 'EDTA'

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