About: Inactivation analysis of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents and fixatives

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About: Inactivation analysis of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents and fixatives Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inactivation analysis of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents and fixatives
Creator	Guiver, Malcolm Jones, Matthew Buczkowski, Hubert Cane, Patricia Welch, Stephen Burton, Jane Green, Nicole Arnold, Ulrike Bruce, Davies, Katherine Evans, Reah Hannah, Matthew Hettiarachchi, Nipunadi Killip, Marian Roberts, Allen Woodford, Neil
Source	BioRxiv
abstract	The COVID-19 pandemic has necessitated a rapid multi-faceted response by the scientific community, bringing researchers, health officials and industry together to address the ongoing public health emergency. To meet this challenge, participants need an informed approach for working safely with the etiological agent, the novel human coronavirus SARS-CoV-2. Work with infectious SARS-CoV-2 is currently restricted to high-containment laboratories, but material can be handled at a lower containment level after inactivation. Given the wide array of inactivation reagents that are being used in laboratories during this pandemic, it is vital that their effectiveness is thoroughly investigated. Here, we evaluated a total of 23 commercial reagents designed for clinical sample transportation, nucleic acid extraction and virus inactivation for their ability to inactivate SARS-CoV-2, as well as seven other common chemicals including detergents and fixatives. As part of this study, we have also tested five filtration matrices for their effectiveness at removing the cytotoxic elements of each reagent, permitting accurate determination of levels of infectious virus remaining following treatment. In addition to providing critical data informing inactivation methods and risk assessments for diagnostic and research laboratories working with SARS-CoV-2, these data provide a framework for other laboratories to validate their inactivation processes and to guide similar studies for other pathogens.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1101/2020.07.08.194613
has license	biorxiv
sha1sum (hex)	fc0dd268287d891e6edc915886d2ec574249c81b
schema:url	https://doi.org/10.1101/2020.07.08.194613
resource representing a document's title	Inactivation analysis of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents and fixatives
schema:publication	bioRxiv
resource representing a document's body	covid:fc0dd268287d891e6edc915886d2ec574249c81b#body_text
is schema:about of	named entity 'permitting' named entity 'human' named entity 'virus' named entity 'laboratories' named entity 'Prevention' named entity 'address' named entity 'data' named entity 'Disease Control' named entity 'laboratories' named entity 'carried' named entity 'specimens' named entity 'rapid' named entity 'transport' named entity 'fixatives' named entity 'PATHOGENS' named entity 'GUIDANCE' named entity 'PART OF' named entity 'HEALTH' named entity 'HANDLING' named entity 'NON-' named entity 'TRANSPORTATION' named entity 'SAMPLES' named entity 'MULTI' named entity 'PARTICIPANTS' named entity 'ACID' named entity 'RESEARCHERS' named entity 'PATHOGEN' named entity 'LEVELS' named entity 'concentration' named entity 'cytotoxic' named entity 'scientific community' named entity 'effectiveness' named entity 'CL2' named entity 'guide' named entity 'England' named entity 'chemicals' named entity 'risk' named entity 'concentration' named entity 'pathogens' named entity 'validation' named entity 'data' named entity 'officials' named entity 'participants' named entity 'public health emergency' named entity 'SARS-CoV-2' named entity 'detergents' named entity 'research laboratories' named entity 'health officials' named entity 'SARS-CoV-2' named entity 'reagent' named entity 'sample matrix' named entity 'risk assessments' named entity 'SARS-CoV-2' named entity 'Public Health' named entity 'clinical samples' named entity 'SARS-CoV-2' named entity 'scientific community' named entity 'WHO' named entity 'nucleic acid' named entity 'pathogens' named entity 'SARS' named entity 'BSL-2' named entity 'Disease Control and Prevention' named entity 'fixatives' named entity 'tissue culture' named entity 'resin' named entity 'COVID-19 pandemic' named entity 'reagent' named entity 'Triton X-100'

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