About: Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families

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About: Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families
Creator	Carta, Antonio Corona, Paola Piras, Sandra Briguglio, Irene
Source	Medline; PMC
abstract	Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one or more of the following mechanisms: inhibition of the NTPase activity, by interferences with ATP binding and therefore by limiting the energy required for the unwinding and translocation, or by allosteric mechanism and therefore by stabilizing the conformation of the enzyme in low helicase activity state; inhibition of nucleic acids binding to the helicase; inhibition of coupling of ATP hydrolysis to unwinding; inhibition of unwinding by sterically blocking helicase translocation. Recently, by in vitro screening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging to Flaviviridae, Coronaviridae, and Picornaviridae families.
has issue date	2010-11-14(xsd:dateTime)
bibo:doi	10.1155/2011/213135
bibo:pmid	27516903
has license	cc-by
sha1sum (hex)	fc151568de57c0456578757131c3b49b86286b3c
schema:url	https://doi.org/10.1155/2011/213135
resource representing a document's title	Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families
has PubMed Central identifier	PMC4970650
has PubMed identifier	27516903
schema:publication	Int J Med Chem
resource representing a document's body	covid:fc151568de57c0456578757131c3b49b86286b3c#body_text
is schema:about of	named entity 'PICORNAVIRIDAE' named entity 'INHIBITION' named entity 'Flaviviridae' named entity 'activity' named entity 'allosteric' named entity 'ATP hydrolysis' named entity 'viral infections' named entity 'inhibition' named entity 'REPORTED' named entity 'GENOME' named entity 'PEPTIDE' named entity 'TROPOLONE' named entity 'SMALL' named entity 'IMIDAZODIAZEPINE' named entity 'INHIBITION' named entity 'FLAVIVIRIDAE' named entity 'LIMITING' named entity 'CORONAVIRIDAE' named entity 'FLAVIVIRIDAE' named entity 'IN VITRO' named entity 'STRATEGIES' named entity 'SCREENING' named entity 'VIRAL INFECTIONS' named entity 'ENERGY' named entity 'SELECTIVE' named entity 'FUNCTIONS' named entity 'ANTHRACYCLINE' named entity 'CONFORMATION' named entity 'DISPLAY' named entity 'RECENTLY' named entity 'BINDING' named entity 'IMIDAZOLE' named entity 'TREATMENT' named entity 'FAMILIES' named entity 'ENCODE' named entity 'COUPLING' named entity 'BANANIN' named entity 'NAMED' named entity 'STATE' named entity 'NTPASE ACTIVITY' named entity 'SSRNA' named entity 'ALLOSTERIC MECHANISM' named entity 'BELONGING' named entity 'ATP BINDING' named entity 'BENZOTRIAZOLE' named entity 'SPECIFIC' named entity 'REPLICATION' named entity 'TRIPHENYLMETHANE' named entity 'DESIGN' named entity 'NUCLEIC ACIDS' named entity 'MECHANISMS' named entity 'ACT' named entity 'CORONAVIRIDAE' named entity 'QUINOLINE' named entity 'RNA HELICASES' named entity 'REQUIRED' named entity 'ACRIDONE' named entity 'PYRROLE' named entity 'VIRUSES' named entity 'PATHOGEN' named entity 'LOW' named entity 'HELICASE' named entity 'TRANSLOCATION' named entity 'ENZYME' named entity 'STUDIES' named entity 'VARIOUS' named entity 'PHENOTHIAZINE' named entity 'PICORNAVIRIDAE' named entity 'VIRUS' named entity 'HELICASE ACTIVITY' named entity 'MOTOR PROTEINS' named entity 'FAMILIES' named entity 'GENERAL' named entity 'BLOCKING' named entity 'BELONGING' named entity 'ATP HYDROLYSIS' named entity 'FOLLOWING' named entity 'VIRAL PATHOGENS'

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