About: Molecular Mechanism of Drug Resistance

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Molecular Mechanism of Drug Resistance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular Mechanism of Drug Resistance
Creator	Suar, Mrutyunjay Das, Susmita Ray, Shilpa
source	PMC
abstract	The treatment of microbial infections has suffered greatly in this present century of pathogen dominance. Inspite of extensive research efforts and scientific advancements, the worldwide emergence of microbial tolerance continues to plague survivability. The innate property of microbe to resist any antibiotic due to evolution is the virtue of intrinsic resistance. However, the classical genetic mutations and extrachromosomal segments causing gene exchange attribute to acquired tolerance development. Rampant use of antimicrobials causes certain selection pressure which increases the resistance frequency. Genomic duplication, enzymatic site modification, target alteration, modulation in membrane permeability, and the efflux pump mechanism are the major contributors of multidrug resistance (MDR), specifically antibiotic tolerance development. MDRs will lead to clinical failures for treatment and pose health crisis. The molecular mechanisms of antimicrobial resistance are diverse as well as complex and still are exploited for new discoveries in order to prevent the surfacing of “superbugs.” Antimicrobial chemotherapy has diminished the threat of infectious diseases to some extent. To avoid the indiscriminate use of antibiotics, the new ones licensed for use have decreased with time. Additionally, in vitro assays and genomics for anti-infectives are novel approaches used in resolving the issues of microbial resistance. Proper use of drugs can keep it under check and minimize the risk of MDR spread.
has issue date	2017-03-22(xsd:dateTime)
bibo:doi	10.1007/978-3-319-48683-3_3
has license	no-cc
sha1sum (hex)	fc25109dbb0819b05c70c8c10a97258b788464dc
schema:url	https://doi.org/10.1007/978-3-319-48683-3_3
resource representing a document's title	Molecular Mechanism of Drug Resistance
has PubMed Central identifier	PMC7122190
schema:publication	Drug Resistance in Bacteria, Fungi, Malaria, and Cancer
resource representing a document's body	covid:fc25109dbb0819b05c70c8c10a97258b788464dc#body_text
is schema:about of	named entity 'treatment' named entity 'acquired' named entity 'intrinsic' named entity 'infectious diseases' named entity 'prevent' named entity 'TOLERANCE' named entity 'MOLECULAR' named entity 'SEGMENTS' named entity 'ANTIBIOTIC' named entity 'APPROACHES' named entity 'TO PREVENT' named entity 'TO AVOID' named entity 'ANTIMICROBIALS' named entity 'DRUGS' named entity 'extensive' named entity 'microbial' named entity 'antimicrobial resistance' named entity 'selection pressure' named entity 'microbe' named entity 'attribute' named entity 'health' named entity 'avoid' named entity 'antimicrobials' named entity 'genomics' named entity 'continues' named entity 'drugs' named entity 'antimicrobial resistance' named entity 'evolution' named entity 'antibiotic' named entity 'molecular mechanisms' named entity 'extrachromosomal' named entity 'superbugs' named entity 'chromosome' named entity 'virulence determinants' named entity 'ERG3' named entity 'Enterococcus' named entity 'asexual' named entity 'gene p53' named entity 'antifungal' named entity 'multidrug efflux' named entity 'aminoglycoside' named entity 'C. albicans' named entity 'Sulfadoxine' named entity 'gene' named entity 'lactone' named entity 'ABC' named entity 'gene' named entity 'Gram-negative' named entity 'ATP-binding cassette' named entity 'telbivudine' named entity 'antibacterials' named entity 'isoniazid' named entity 'molecular mechanism' named entity 'antibacterial compounds' named entity 'salmonellosis' named entity 'paclitaxel' named entity 'heme' named entity 'natural resistance' named entity 'protein' named entity 'phenotype' named entity 'amino acid sequences' named entity 'pharmacokinetic' named entity 'fibroblast' named entity 'operon' named entity 'Chromosomal' named entity 'metabolic' named entity 'gene' named entity 'plasmids' named entity 'dermatophytes' named entity 'hydrolyzing' named entity 'resistance development' named entity 'S. aureus' named entity 'myeloid leukemic' named entity 'pathogens' named entity 'pathogens' named entity 'semisynthetic' named entity 'vancomycin-resistant' named entity 'enzyme' named entity 'active site' named entity 'ergosterol' named entity 'membrane transport'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software