About: Active immunity and T-cell populations in pigs intraperitoneally inoculated with baculovirus-expressed transmissible gastroenteritis virus structural proteins

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About: Active immunity and T-cell populations in pigs intraperitoneally inoculated with baculovirus-expressed transmissible gastroenteritis virus structural proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Active immunity and T-cell populations in pigs intraperitoneally inoculated with baculovirus-expressed transmissible gastroenteritis virus structural proteins
Creator	Saif, L Hayes, J Kim, L Lewis, P Meister, R Myers, G Sestak, K
Source	Elsevier; Medline; PMC
abstract	The intraperitoneal inoculation of pigs with baculovirus-expressed transmissible gastroenteritis virus (TGEV) structural proteins (S, N, M) in conjunction with thermolabile Escherichia coli mutant toxin (LT-R192G) in incomplete Freund’s adjuvant (IFA) was tested in an attempt to elicit active immunity to TGEV in gut-associated lymphoid tissues (GALT). Four groups of 63 (1–5-week-old) suckling, TGEV-seronegative pigs were used to assess the efficacy of the recombinant protein vaccine (group 3) in comparison with sham (group 1), commercial vaccine (group 2), and virulent TGEV Miller-strain-inoculated pigs (group 4). The TGEV-specific mucosal and systemic immune responses were measured after in vivo and in vitro stimulation with TGEV-antigens. The major T-cell subset distribution was analyzed in vivo and in vitro after stimulation of mononuclear cells with TGEV (from mesenteric lymph nodes of group 3 inoculated with TGEV-recombinant proteins). Induction of active immunity was assessed by challenge of pigs with virulent TGEV at 27 days of age. Baculovirus-expressed TGEV proteins coadministered with LT-R192G in IFA induced mesenteric lymph node immune responses associated with IgA-antibodies to TGEV and partial protection against TGEV-challenge. The high titers of serum IgG- and virus-neutralizing-antibodies to TGEV in group 3 pigs most likely reflected the dose of TGEV S-protein administered. At the day of TGEV-challenge, the in vitro stimulation of mononuclear cells from the mesenteric lymph nodes of group 3 pigs with inactivated TGEV resulted in an increase in double positive (CD4+CD8+), natural killer (CD2+CD4−CD8+dim) and cytotoxic (CD2+CD4−CD8+bright) T-cell phenotypes, accompanied by increased expression of interleukin-2 receptor and a decrease of the null (CD2−CD4−CD8−/SW6+) cell phenotype.
has issue date	1999-09-20(xsd:dateTime)
bibo:doi	10.1016/s0165-2427(99)00074-4
bibo:pmid	10507362
has license	no-cc
sha1sum (hex)	fc4689e9a0f8c2d5711673eda0dc66be1a820fe2
schema:url	https://doi.org/10.1016/s0165-2427%2899%2900074-4
resource representing a document's title	Active immunity and T-cell populations in pigs intraperitoneally inoculated with baculovirus-expressed transmissible gastroenteritis virus structural proteins
has PubMed Central identifier	PMC7119614
has PubMed identifier	10507362
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:fc4689e9a0f8c2d5711673eda0dc66be1a820fe2#body_text
is schema:about of	named entity 'subset' named entity 'toxin' named entity 'sham' named entity 'natural killer' named entity 'thermolabile' named entity 'mutant' named entity 'pigs' named entity 'virulent' named entity 'titers' named entity 'INOCULATION' named entity 'IN VITRO' named entity '203' named entity 'PIGS' named entity 'STRUCTURAL PROTEINS' named entity 'SYSTEMIC' named entity 'PROTECTION' named entity 'T-CELL' named entity 'IGG' named entity 'DOSE' named entity '28S' named entity 'INDUCTION' named entity 'USED' named entity 'LYMPHOID TISSUES' named entity 'B1221' named entity 'CHALLENGE' named entity 'POSITIVE' named entity 'MESENTERIC LYMPH NODES' named entity 'IMMUNOPATHOLOGY' named entity 'PIGS' named entity 'ACTIVE IMMUNITY' named entity 'REFLECTED' named entity 'INDUCED' named entity 'INACTIVATED' named entity 'PHENOTYPES' named entity 'VIRUS' named entity 'PARTIAL' named entity 'SPECIFIC' named entity 'SHAM' named entity 'ANTIGENS' named entity 'ADJUVANT' named entity 'INCOMPLETE' named entity 'EXPRESSED' named entity 'STRUCTURAL PROTEINS' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'T-CELL' named entity 'PROTEIN ' named entity 'INCREASE' named entity 'BACULOVIRUS' named entity 'DECREASE' named entity 'ASSOCIATED' named entity 'VACCINE' named entity 'S-PROTEIN' named entity 'ANTIBODIES' named entity 'ACTIVE IMMUNITY' named entity 'BACULOVIRUS' named entity 'DAYS' named entity 'SUBSET' named entity 'OLD' named entity 'ASSOCIATED WITH' named entity 'HIGH' named entity 'DISTRIBUTION' named entity 'ANALYZED' named entity 'EXPRESSED' named entity 'NATURAL KILLER' named entity 'ADMINISTERED' named entity 'MAJOR' named entity 'MONONUCLEAR CELLS' named entity 'IFA' named entity 'SERUM' named entity 'DAY' named entity 'IGA' named entity 'ELICIT' named entity 'BY INCREASED' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'CELL PHENOTYPE'

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