About: Foxp3(+) T(reg) cells in humoral immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Foxp3(+) T(reg) cells in humoral immunity
Creator	Sakaguchi, Shimon Wing, James
Source	Medline; PMC
abstract	T(reg) cells are essential for the maintenance of immune homeostasis and prevention of autoimmunity. In humoral immune responses, loss of T(reg) cell function causes increased levels of serum autoantibodies, hyper-IgE, spontaneous generation of germinal centres, and enhanced numbers of specialised T follicular helper cells (T(fh) cells) controlled by the lineage-defining transcription factor BCL-6 (B-cell lymphoma 6). Recent studies have demonstrated that a subset of T(reg) cells [T follicular regulatory (T(freg)) cells] are able to co-opt the follicular T-cell program by gaining expression of BCL-6 and travelling to the follicle where they have an important role in the control of expansion of T(fh) cells and the germinal centre reaction. However, the mechanisms by which they exert this control are still under investigation. In this review, we discuss the effects of T(reg) cells on humoral immunity and the mechanisms by which they exert their regulatory function.
has issue date	2013-12-09(xsd:dateTime)
bibo:doi	10.1093/intimm/dxt060
bibo:pmid	24324208
has license	no-cc
sha1sum (hex)	fc4a1614aae7eb5219bf21bbdf82e0b61576faf6
schema:url	https://doi.org/10.1093/intimm/dxt060
resource representing a document's title	Foxp3(+) T(reg) cells in humoral immunity
has PubMed Central identifier	PMC7108613
has PubMed identifier	24324208
schema:publication	Int Immunol
resource representing a document's body	covid:fc4a1614aae7eb5219bf21bbdf82e0b61576faf6#body_text
is schema:about of	named entity 'However' named entity 'cells' named entity 'REGULATORY' named entity 'MECHANISMS' named entity 'CONTROL' named entity 'EFFECTS' named entity 'CELLS' named entity 'THEIR' named entity 'HUMORAL IMMUNITY' named entity 'HUMORAL IMMUNITY' named entity 'GERMINAL' named entity 'T REG' named entity 'CELLS' named entity 'DISCUSS' named entity 'INVESTIGATION' named entity 'FOXP3' named entity 'REVIEW' named entity 'EXERT' named entity 'T REG' named entity 'REACTION' named entity 'FUNCTION' named entity 'CENTRE' named entity 'function' named entity 'humoral immunity' named entity 'humoral immunity' named entity 'thymus' named entity 'IL-10' named entity 'high-affinity' named entity 'B-cell lymphoma' named entity 'myosin' named entity 'NZB' named entity 'IPEX' named entity 'NZW' named entity 'non-self' named entity 'CTLA-4' named entity 'BCL-6' named entity 'antibody' named entity 'germinal centre' named entity 'negative selection' named entity 'ICOS' named entity 'perforin' named entity 'solubilized' named entity 'humoral immunity' named entity 'antigen' named entity 'tetramer' named entity 'CD8 +' named entity 'lupus' named entity 'IL-4' named entity 'cell function' named entity 'dose-dependent' named entity 'isotype' named entity 'exact mechanism' named entity 'CTLA-4' named entity 'high-affinity' named entity 'hyper-IgE' named entity 'long-lasting' named entity 'antibody' named entity 'antigen' named entity 'germinal centres' named entity 'CTLA-4' named entity 'germinal centre' named entity 'antibody' named entity 'non-self' named entity 'Foxp3' named entity 'B-cell' named entity 'mRNA expression' named entity 'plasma cells' named entity 'antigen' named entity 'TCRs' named entity 'CTLA-4' named entity 'humoral immunity' named entity 'follicle' named entity 'Fas' named entity 'KO mice' named entity 'IL-10' named entity 'effector T cell' named entity 'IL-4' named entity 'arthritis' named entity 'high-affinity' named entity 'immune dysregulation'

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