About: Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis

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About: Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis
Creator	Vuorinen, Tytti Elenius, Varpu Jartti, Tuomas Waris, Matti Akdis, Mübeccel Mikola, Emilia Palomares, Oscar Puhakka, Tuomo Rückert, Beate Turunen, Riitta Allander, Tobias Vahlberg, Tero Aab, Alar Ivaska, Lotta Saarinen, Maria Akdis, Cezmi Camargo, Carlos
Source	Medline; PMC
abstract	BACKGROUND: Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis. METHODS: Tonsils of 89 surgical patients with tonsillar hypertrophy (n = 47) or recurrent tonsillitis (n = 42) were analysed. Patients were carefully characterized clinically. Standard questionnaire was used to asses preceding and allergy symptoms. Respiratory viruses were analysed in tonsils and nasopharynx by PCR. Quantitative real-time PCR was used to analyse intratonsillar gene expressions of IFN-α, IFN-β, IFN-γ, IL-10, IL-13, IL-17, IL-28, IL-29, IL-37, TGF-β, FOXP3, GATA3, RORC2 and Tbet. RESULTS: Median age of the subjects was 15 years (range 2–60). Patients with tonsillar hypertrophy were younger, smoked less often, had less pollen allergy and had more adenovirus, bocavirus-1, coronavirus and rhinovirus in nasopharynx (all P < 0.05). Only bocavirus-1 was more often detected in hypertrophic tonsils (P < 0.05). In age-adjusted analysis, tonsillar hypertrophy was associated with higher mRNA expressions of IL-37 (P < 0.05). CONCLUSIONS: Intratonsillar T cell and interferon gene expressions appeared to be relatively stable for both tonsillar hypertrophy and recurrent tonsillitis. Of the studied cytokines, only newly discovered anti-inflammatory cytokine IL-37, was independently associated with tonsillar hypertrophy showing slightly stronger anti-inflammatory response in these patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13601-018-0205-z) contains supplementary material, which is available to authorized users.
has issue date	2018-05-22(xsd:dateTime)
bibo:doi	10.1186/s13601-018-0205-z
bibo:pmid	29942488
has license	cc-by
sha1sum (hex)	fc83785220bddefb3ae13e33fc3a49f9290cdc84
schema:url	https://doi.org/10.1186/s13601-018-0205-z
resource representing a document's title	Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis
has PubMed Central identifier	PMC5963068
has PubMed identifier	29942488
schema:publication	Clin Transl Allergy
resource representing a document's body	covid:fc83785220bddefb3ae13e33fc3a49f9290cdc84#body_text
is schema:about of	named entity 'PATIENTS' named entity 'immune response' named entity 'infections' named entity 'provide' named entity 'hypertrophy' named entity 'DUE TO' named entity 'INVESTIGATING' named entity 'VIRUS DETECTION' named entity 'RESPONSE TO' named entity 'GENE EXPRESSION' named entity 'RECURRENT TONSILLITIS' named entity 'ALLERGENS' named entity 'IN VIVO MODEL' named entity 'BACKGROUND' named entity 'PROVIDE' named entity 'IMMUNE RESPONSE' named entity 'T CELL' named entity 'INFECTIONS' named entity 'INTERFERON ' named entity 'TONSILLAR HYPERTROPHY' named entity 'TONSILLAR' named entity 'DATA' named entity 'TONSILLECTOMY' named entity 'TONSILS' named entity 'CYTOKINE EXPRESSION' named entity 'VIRUS' named entity 'RECURRENT TONSILLITIS' named entity 'TONSILLAR HYPERTROPHY' named entity 'PATIENTS' covid:arg/fc83785220bddefb3ae13e33fc3a49f9290cdc84 named entity 'patients' named entity 'tonsillectomy' named entity 'expression' named entity 'virus' named entity 'data' named entity 'tonsillectomy' named entity 'tonsillitis' named entity 'tonsillitis' named entity 'Tonsils' named entity 'immune responses' named entity 'cytokine' named entity 'tonsil' named entity 'protein' named entity 'TNF-α' named entity 'IL-37' named entity 'Cary, NC' named entity 'IFN' named entity 'IL-37' named entity 'Finland' named entity 'Fermentas' named entity 'food allergies' named entity 'tonsillitis' named entity 'IL-37' named entity 'IL-37' named entity 'IL-37' named entity 'hypertrophy' named entity 'immunoassay' named entity 'tonsillitis' named entity 'tonsil' named entity 'Virus' named entity 'IL-10' named entity 'interferon' named entity 'tonsillectomy' named entity 'SAS Institute' named entity 'regression analysis'

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