About: What every Intensivist should know about COVID-19 associated acute kidney injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	What every Intensivist should know about COVID-19 associated acute kidney injury
Creator	Forni, Lui Ostermann, Marlies Hoste, Eric Lumlertgul, Nuttha Ostermann Guy's &, Marlies Thomas' Hospital, St
source	Elsevier; Medline; PMC
abstract	Acute kidney injury (AKI) is a serious complication in critically ill patients with COVID-19 with a reported incidence ranging from <5% to >25%. Proposed aetiologies include hypovolemia, hemodynamic disturbance and inflammation but also specific factors like direct viral invasion, microvascular thrombosis, and altered regulation of the renin-angiotensin-aldosterone system. To date, there are no confirmed specific therapies, and prevention and management of AKI should follow established guidelines. Novel therapies specifically targeting COVID-19 related pathologies are under investigation. The incidence of renal replacement therapy (RRT) is variable, ranging from 0-37%. In a pandemic, RRT practice is likely to be determined by the number of patients, availability of machines, consumables and staff, clinical expertise, and acceptable alternatives. Close collaboration between critical care and renal services is essential. In this article, we describe the epidemiology and pathophysiology of COVID-19 associated AKI, outline current management and suggest strategies to provide RRT during a pandemic when resources may be scarce.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.1016/j.jcrc.2020.07.023
bibo:pmid	32777758
has license	no-cc
sha1sum (hex)	fcc0b64c6a03287cabea2b2bd3985e0b7b1d583d
schema:url	https://doi.org/10.1016/j.jcrc.2020.07.023
resource representing a document's title	What every Intensivist should know about COVID-19 associated acute kidney injury
has PubMed Central identifier	PMC7386261
has PubMed identifier	32777758
schema:publication	J Crit Care
resource representing a document's body	covid:fcc0b64c6a03287cabea2b2bd3985e0b7b1d583d#body_text
is schema:about of	named entity 'Journal' named entity 'Journal' named entity 'What' named entity 'COVID-19' named entity 'Email' named entity 'acute kidney injury' named entity 'COVID-19' named entity 'COVID' named entity 'tissue factor' named entity 'SARS-CoV-2' named entity 'RRT' named entity 'AKI' named entity 'peptide' named entity 'Ang-II' named entity 'COVID' named entity 'incidence rates' named entity 'AKI' named entity 'COVID' named entity 'renal replacement therapy' named entity 'histology' named entity 'ACE2 receptor' named entity 'cytokines' named entity 'hyperkalemia' named entity 'reverse osmosis' named entity 'AKI' named entity 'peritubular capillaries' named entity 'replicase' named entity 'RAAS' named entity 'viral infections' named entity 'proning' named entity 'IHD' named entity 'IHD' named entity 'cytotoxicity' named entity 'extracorporeal membrane oxygenation' named entity 'critically ill patients' named entity 'peritubular capillaries' named entity 'COVID-19 pandemic' named entity 'reverse osmosis' named entity 'socioeconomic' named entity 'cytokine' named entity 'high levels' named entity 'renal replacement therapy' named entity 'podocytes' named entity 'ACE2' named entity 'autoimmune diseases' named entity 'Post-mortem' named entity 'COVID' named entity 'RRT' named entity 'podocytes' named entity 'coagulation factors' named entity 'interstitium' named entity 'kidney' named entity 'angiotensin' named entity 'COVID-19' named entity 'inflammatory cells' named entity 'antigen' named entity 'COVID-19' named entity 'human immunodeficiency virus' named entity 'microcirculation' named entity 'hypotension' named entity 'vasodilation' named entity 'influenza' named entity 'adsorption' named entity 'ICUs' named entity 'spike (S) protein' named entity 'RRT' named entity 'proteinuria' named entity 'transcriptional processes' named entity 'RRT' named entity 'virions' named entity 'histology' named entity 'antibodies' named entity 'Continuous renal replacement therapy' named entity 'cytosol' named entity 'COVID' named entity 'physical and emotional'

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