About: The first complete genome sequences of clinical isolates of human coronavirus 229E

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The first complete genome sequences of clinical isolates of human coronavirus 229E
Creator	Dijkman, Ronald Molenkamp, Richard Deijs, Martin Goossens, Herman Ieven, Margareta Farsani, Jazaeri Mohammad, Seyed Van Der Hoek, Lia Jebbink, F Maarten, •
source	Medline; PMC
abstract	Human coronavirus 229E has been identified in the mid-1960s, yet still only one full-genome sequence is available. This full-length sequence has been determined from the cDNA-clone Inf-1 that is based on the lab-adapted strain VR-740. Lab-adaptation might have resulted in genomic changes, due to insufficient pressure to maintain gene integrity of non-essential genes. We present here the first full-length genome sequence of two clinical isolates. Each encoded gene was compared to Inf-1. In general, little sequence changes were noted, most could be attributed to genetic drift, since the clinical isolates originate from 2009 to 2010 and VR740 from 1962. Hot spots of substitutions were situated in the S1 region of the Spike, the nucleocapsid gene, and the non-structural protein 3 gene, whereas several deletions were detected in the 3′UTR. Most notable was the difference in genome organization: instead of an ORF4A and ORF4B, an intact ORF4 was present in clinical isolates.
has issue date	2012-08-25(xsd:dateTime)
bibo:doi	10.1007/s11262-012-0807-9
bibo:pmid	22926811
has license	no-cc
sha1sum (hex)	fccba984e421b3df0ba8cae61b62fa6ac4700efa
schema:url	https://doi.org/10.1007/s11262-012-0807-9
resource representing a document's title	The first complete genome sequences of clinical isolates of human coronavirus 229E
has PubMed Central identifier	PMC7088690
has PubMed identifier	22926811
schema:publication	Virus Genes
resource representing a document's body	covid:fccba984e421b3df0ba8cae61b62fa6ac4700efa#body_text
is schema:about of	named entity 'SEQUENCES' named entity 'CLINICAL' named entity 'HERE' named entity 'PRESSURE' named entity 'COULD BE' named entity 'GENES' named entity 'PRESENT' named entity 'INTEGRITY OF' named entity 'COMPARED' named entity 'REGION' named entity 'ORF4' named entity 'UTR' named entity 'DETECTED' named entity 'NON-STRUCTURAL PROTEIN 3' named entity 'CHANGES' named entity 'GENETIC DRIFT' covid:arg/fccba984e421b3df0ba8cae61b62fa6ac4700efa named entity '740' named entity 'BASED' named entity 'TO MAINTAIN' named entity 'ENCODED' named entity 'INSUFFICIENT' named entity 'CLONE' named entity 'IDENTIFIED' named entity 'HUMAN CORONAVIRUS 229E' named entity 'ISOLATES' named entity 'ISOLATES' named entity '1962' named entity 'NON-ESSENTIAL' named entity 'GENOME' named entity 'COMPLETE' named entity 'SEQUENCE' named entity 'ADAPTED' named entity 'GENERAL' named entity 'ADAPTATION' named entity 'MID' named entity 'GENE' named entity 'INF-1' named entity 'GENOMIC' named entity 'NOTED' named entity 'HUMAN CORONAVIRUS 229E' named entity 'LITTLE' named entity 'HAVE' named entity 'DETERMINED' named entity 'GENOME SEQUENCE' named entity 'HOT SPOTS' named entity 'LAB' named entity 'NUCLEOCAPSID' named entity 'GENOME ORGANIZATION' named entity 'DUE TO' named entity 'AVAILABLE' named entity 'STRAIN' named entity 'SPIKE' named entity 'DIFFERENCE' named entity 'CDNA' named entity 'LENGTH' named entity 'CLINICAL' named entity 'INTACT' named entity 'gene' named entity 'UTR' named entity 'genome sequence' named entity 'gene' named entity 'deletions' named entity 'non-essential genes' named entity 'nucleocapsid' named entity 'genome sequences' named entity '4.02' named entity 'Chibu' named entity 'UTR' named entity 'protein' named entity 'alphacoronavirus' named entity 'genome'

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