About: Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance
Creator	Hashemi, Elaheh Malarkannan, Subramaniam
Source	Medline; PMC
abstract	Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in killing infected or transformed cells. NK cells mediate their effector functions using non-clonotypic germ-line-encoded activation receptors. The utilization of non-polymorphic and conserved activating receptors promoted the conceptual dogma that NK cells are homogeneous with limited but focused immune functions. However, emerging studies reveal that NK cells are highly heterogeneous with divergent immune functions. A distinct combination of several activation and inhibitory receptors form a diverse array of NK cell subsets in both humans and mice. Importantly, one of the central factors that determine NK cell heterogeneity and their divergent functions is their tissue residency. Decades of studies provided strong support that NK cells develop in the bone marrow. However, evolving evidence supports the notion that NK cells also develop and differentiate in tissues. Here, we summarize the molecular basis, phenotypic signatures, and functions of tissue-resident NK cells and compare them with conventional NK cells.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.3390/cancers12061553
bibo:pmid	32545516
has license	cc-by
sha1sum (hex)	fcd0b06a08e6e8d936f7c4a5aa90786a468b72df
schema:url	https://doi.org/10.3390/cancers12061553
resource representing a document's title	Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance
has PubMed Central identifier	PMC7352973
has PubMed identifier	32545516
schema:publication	Cancers (Basel)
resource representing a document's body	covid:fcd0b06a08e6e8d936f7c4a5aa90786a468b72df#body_text
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