About: Tumor necrosis factor α gene expression and the response to interferon in chronic hepatitis C

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Tumor necrosis factor α gene expression and the response to interferon in chronic hepatitis C
Creator	Cheng Qian, Maria Civeira, Jesú Garcia, Nicolá Larrea, Esther Prieto, Prieto, Jesú
source	Medline; PMC
abstract	Tumor necrosis factor α (TNF‐α) is a cytokine with pleiotropic properties that is induced in a variety of pathological situations including viral infections. In this work, we analyzed the expression of TNF‐α gene in patients with chronic hepatitis C. Serum TNF‐α levels were found to be elevated in all chronic hepatitis C patients including those cases presenting sustained biochemical remission of the disease after interferon therapy. Untreated patients with chronic hepatitis C showed increased TNF‐α messenger RNA (mRNA) levels in the liver and mononuclear cells as compared with healthy controls. After completion of treatment with interferon, patients experiencing sustained complete response showed values of TNF‐α mRNA, both in the liver and in peripheral mononuclear cells, within the normal range, significantly lower than patients who did not respond to interferon and than those with complete response who relapsed after interferon withdrawal. Pretreatment values of TNF‐α mRNA were lower in long‐term responders to interferon than in cases who failed to respond to the treatment. Values of TNF‐α mRNA in the liver or in mononuclear cells were higher in specimens with positive hepatitis C virus (HCV) RNA than in those samples where the virus was undetectable. Neither the intensity of the liver damage nor the amount of HCV RNA in serum or in cells showed correlation with the levels of TNF‐α transcripts in peripheral mononuclear cells but it was found that high TNF‐α values were associated with genotype 1b. In conclusion, there is an enhanced expression of TNF‐α in HCV infection. High levels of this cytokine may play a role in the resistance to interferon therapy.
has issue date	2003-12-30(xsd:dateTime)
bibo:doi	10.1002/hep.510230203
bibo:pmid	8591843
has license	no-cc
sha1sum (hex)	fcd5ccb7b4bdbcf613e747604e2a941583b738c1
schema:url	https://doi.org/10.1002/hep.510230203
resource representing a document's title	Tumor necrosis factor α gene expression and the response to interferon in chronic hepatitis C
has PubMed Central identifier	PMC7165845
has PubMed identifier	8591843
schema:publication	Hepatology
resource representing a document's body	covid:fcd5ccb7b4bdbcf613e747604e2a941583b738c1#body_text
is schema:about of	named entity 'necrosis' named entity 'TNF-a' named entity 'INCLUDING' named entity 'PROPERTIES' named entity 'INFECTIOUS AGENTS' named entity 'CYTOKINE ' named entity 'infectious agents' named entity 'Although' named entity 'TNF-a' named entity 'Serum' named entity 'TNF-a' named entity 'antiviral' named entity 'TNF-a' named entity 'Tumor Necrosis Factor' named entity 'serum' named entity 'IFN-a' named entity 'TNF-a' named entity 'agarose gel' named entity 'mRNA' named entity 'interferon' named entity 'mRNA' named entity 'Promega Corporation' named entity 'PBMC' named entity 'HCV' named entity 'transcriptional' named entity 'pH 8' named entity 'HCV' named entity 'IFN-a' named entity 'PBMC' named entity 'Histological' named entity 'mRNA' named entity 'TNF-a' named entity 'RNA' named entity 'HCV' named entity 'interferon' named entity 'RNA' named entity 'actin' named entity 'lymphoid' named entity 'PBMC' named entity 'TNF-a' named entity 'chronic viral hepatitis' named entity 'liver' named entity 'riboprobe' named entity 'BglII' named entity 'serum' named entity '0.9' named entity 'cDNA' named entity 'deoxynucleoside triphosphate' named entity 'TNF-a' named entity 'liver' named entity 'TNF-a' named entity 'HCV genotypes' named entity 'relapse' named entity 'RNA' named entity 'cDNA' named entity 'PCR technique' named entity 'serum' named entity 'complete response' named entity 'RNA' named entity 'primers' named entity 'mmol/L' named entity 'liver' named entity 'lesion' named entity 'PCR reaction' named entity 'EcoRI' named entity 'liver biopsy' named entity 'radioactivities' named entity 'TNF-a' named entity 'TNF-a' named entity 'liver' named entity 'TNF-a' named entity 'mCi' named entity 'cDNA' named entity 'liver' named entity 'PBMC' named entity 'RNA'

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