About: Studying Human Pathogens in Animal Models: Fine Tuning the Humanized Mouse

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Studying Human Pathogens in Animal Models: Fine Tuning the Humanized Mouse
Creator	Enjuanes, Luis Strobl, Birgit Lassnig, Caroline Kolb, Andreas Mu¨ller, Mathias
source	Medline; PMC
abstract	Humanized mice are crucial tools for studying human pathogens in systemic situations. An animal model of human coronavirus infectious disease has been generated by gene transfer of the human receptor for virus-cell interaction (aminopeptidase N, APN, CD13) into mice. We showed that in vitro and in vivo infections across the species barrier differ in their requirements. Transgenic cells were susceptible to human coronavirus HCoV-229E infection demonstrating the requirement of hAPN for viral cell entry. Transgenic mice, however, could not be infected suggesting additional requirements for in vivo virus susceptibility. Crossing hAPN transgenic mice with interferon unresponsive Stat1(−/− )mice resulted in markedly enhanced virus replication in vitro but did not result in detectable virus replication in vivo. Adaptation of the human virus to murine cells led to successful infection of the humanized transgenic mice. Future genetic engineering approaches are suggested to provide animal models for the better understanding of human infectious diseases.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1007/s11248-005-1676-y
bibo:pmid	16315087
has license	no-cc
sha1sum (hex)	fcd73cddaa78ae7185f458cb4222556270e30876
schema:url	https://doi.org/10.1007/s11248-005-1676-y
resource representing a document's title	Studying Human Pathogens in Animal Models: Fine Tuning the Humanized Mouse
has PubMed Central identifier	PMC7088949
has PubMed identifier	16315087
schema:publication	Transgenic Res
resource representing a document's body	covid:fcd73cddaa78ae7185f458cb4222556270e30876#body_text
is schema:about of	named entity 'coronavirus' named entity 'infectious diseases' named entity 'human' named entity 'mice' named entity 'studying' named entity 'replication' named entity 'pathogens' named entity 'humanized' named entity 'tools' covid:arg/fcd73cddaa78ae7185f458cb4222556270e30876 named entity 'TRANSGENIC MICE' named entity 'VIRAL' named entity 'VIRUS REPLICATION' named entity 'ENTRY' named entity 'TO PROVIDE' named entity 'IN VIVO' named entity 'APPROACHES' named entity 'FUTURE' named entity 'INTERFERON ' named entity 'BUT' named entity 'INFECTIONS' named entity 'HCOV-229E' named entity 'APN' named entity 'STAT1' named entity 'CROSSING' named entity 'DETECTABLE' named entity 'UNRESPONSIVE' named entity 'SYSTEMIC' named entity 'HUMAN' named entity 'PATHOGENS' named entity 'CD13' named entity 'CORONAVIRUS INFECTIOUS DISEASE' named entity 'MICE' named entity 'TRANSGENIC' named entity 'SPECIES' named entity 'BARRIER' named entity 'THEIR' named entity 'ADAPTATION' named entity 'RESULT' named entity 'BETTER' named entity 'VIRUS SUSCEPTIBILITY' named entity 'HUMANIZED MOUSE' named entity 'HUMAN' named entity 'PATHOGENS' named entity 'MODEL OF' named entity 'HUMANIZED MICE' named entity 'HUMAN CORONAVIRUS' named entity 'SUSCEPTIBLE' named entity 'ANIMAL MODELS' named entity 'TOOLS' named entity 'VIRUS REPLICATION IN VIVO' named entity 'VIRUS-CELL INTERACTION' named entity 'FINE' named entity 'GENETIC ENGINEERING' named entity 'ACROSS' named entity 'ANIMAL MODEL' named entity 'SUCCESSFUL' named entity 'MURINE' named entity 'CELLS' named entity 'ADDITIONAL' named entity 'DID' named entity 'MARKEDLY' named entity 'LED' named entity 'GENERATED' named entity 'HUMAN VIRUS' named entity 'REQUIREMENTS' named entity 'ENHANCED' named entity 'REQUIREMENT' named entity 'GENE TRANSFER' named entity 'UNDERSTANDING' named entity 'INFECTED' named entity 'IN VITRO' named entity 'INFECTION' named entity 'CELL' named entity 'INFECTIOUS DISEASES' named entity 'HUMANIZED' named entity 'RECEPTOR'

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