About: Role of MAPK/MNK1 signaling in virus replication

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About: Role of MAPK/MNK1 signaling in virus replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of MAPK/MNK1 signaling in virus replication
Creator	Kumar, Naveen Barua, Sanjay Khandelwal, Nitin Kumar, Ram Maherchandani, Sunil Thachamvally, Riyesh Kumar Kashyap, Sudhir Nath Tripathi, Bhupendra
topic	covid:fd0764e333ca2dfacecd8ecfdd0965b5000839fd#this
Source	Elsevier; Medline; PMC
abstract	Abstract Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery to effectively replicate and produce new progeny virus particles. Following viral infection, diverse cell signaling pathways are initiated by the cells, with the major goal of establishing an antiviral state. However, viruses have been shown to exploit cellular signaling pathways for their own effective replication. Genome-wide siRNA screens have also identified numerous host factors that either support (proviral) or inhibit (antiviral) virus replication. Some of the host factors might be dispensable for the host but may be critical for virus replication; therefore such cellular factors may serve as targets for development of antiviral therapeutics. Mitogen activated protein kinase (MAPK) is a major cell signaling pathway that is known to be activated by diverse group of viruses. MAPK interacting kinase 1 (MNK1) has been shown to regulate both cap-dependent and internal ribosomal entry sites (IRES)-mediated mRNA translation. In this review we have discuss the role of MAPK in virus replication, particularly the role of MNK1 in replication and translation of viral genome.
has issue date	2018-07-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2018.05.028
bibo:pmid	29864503
has license	els-covid
sha1sum (hex)	fd0764e333ca2dfacecd8ecfdd0965b5000839fd
schema:url	https://doi.org/10.1016/j.virusres.2018.05.028
resource representing a document's title	Role of MAPK/MNK1 signaling in virus replication
has PubMed Central identifier	PMC7114592
has PubMed identifier	29864503
schema:publication	Virus Research
resource representing a document's body	covid:fd0764e333ca2dfacecd8ecfdd0965b5000839fd#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/fd0764e333ca2dfacecd8ecfdd0965b5000839fd
is schema:about of	named entity 'ROLE' named entity 'Some' named entity 'antiviral' named entity 'machinery' named entity 'Mitogen' named entity 'virus' named entity 'MAJOR' named entity 'DIVERSE' named entity 'NEW' named entity 'THERAPEUTICS' named entity 'MRNA TRANSLATION' named entity 'FOLLOWING' named entity 'INTERACTING' named entity 'HOST CELL' named entity 'VIRAL GENOME' named entity 'KNOWN' named entity 'CAP' named entity 'INTERNAL' named entity 'REPLICATE' named entity 'MACHINERY' named entity 'DEVELOPMENT' named entity 'INTRACELLULAR PARASITES' named entity 'GENOME' named entity 'VIRUS REPLICATION' named entity 'NUMEROUS' named entity 'SITES' named entity 'SUPPORT' named entity 'IS A' named entity 'VIRUSES' named entity 'WIDE' named entity 'TO BE ACTIVATED' named entity 'SIGNALING PATHWAY' named entity 'EITHER' named entity 'SIGNALING' named entity 'VIRUS REPLICATION' named entity 'MAPK' named entity 'ESTABLISHING' named entity 'ROLE' named entity 'GOAL' named entity 'TARGETS' named entity 'CELLS' named entity 'DEPEND' named entity 'HOST' named entity 'MITOGEN ACTIVATED PROTEIN KINASE' named entity 'BUT' named entity 'CRITICAL' named entity 'OBLIGATE' named entity 'SIRNA' named entity 'DISCUSS' named entity 'REVIEW' named entity 'ANTIVIRAL' named entity 'TO REGULATE' named entity 'MIGHT BE' named entity 'SIGNALING PATHWAYS' named entity 'STATE' named entity 'EXPLOIT' named entity 'VIRAL INFECTION' named entity 'TRANSLATION' named entity 'PRODUCE' named entity 'A MAJOR' named entity 'SERVE' named entity 'DEPENDENT' named entity 'VIRUS PARTICLES' named entity 'CELLULAR' named entity 'REPLICATION' named entity 'CELL SIGNALING' named entity 'THEIR' named entity 'ENTRY' named entity 'IDENTIFIED' named entity 'MAPK' named entity 'RIBOSOMAL' named entity 'EFFECTIVE'

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