About: Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin

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About: Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin
Creator	Yang, Xiaoming Nagarkatti, Mitzi Bonati, Laura Busbee, Brandon Nagarkatti, Prakash Xing, Yongna Chitrala, Kumaraswamy Singh, Narendra
Source	Medline; PMC
abstract	The toxic manifestations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant, primarily depend on its ability to activate aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor belonging to the superfamily of basic-helix-loop-helix DNA-binding proteins. In the present study, we aimed to identify novel protein receptor targets for TCDD using computational and in vitro validation experiments. Interestingly, results from computational methods predicted that Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) could be one of the potential targets for TCDD in both mouse and humans. Results from molecular docking studies showed that human VEGFR1 (hVEGFR1) has less affinity towards TCDD compared to the mouse VEGFR1 (mVEGFR1). In vitro validation results showed that TCDD can bind and phosphorylate hVEGFR1. Further, results from molecular dynamic simulation studies showed that hVEGFR1 interaction with TCDD is stable throughout the simulation time. Overall, the present study has identified VEGFR1 as a novel target for TCDD, which provides the basis for further elucidating the role of TCDD in angiogenesis.
has issue date	2019-05-02(xsd:dateTime)
bibo:doi	10.1038/s41598-019-43232-4
bibo:pmid	31048752
has license	cc-by
sha1sum (hex)	fd0802a5e13561915fb90cbfe5bb12a751197e28
schema:url	https://doi.org/10.1038/s41598-019-43232-4
resource representing a document's title	Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin
has PubMed Central identifier	PMC6497656
has PubMed identifier	31048752
schema:publication	Sci Rep
resource representing a document's body	covid:fd0802a5e13561915fb90cbfe5bb12a751197e28#body_text
is schema:about of	named entity 'TRANSCRIPTION FACTOR' named entity 'BASIC' named entity 'PRESENT' named entity 'METHODS' named entity 'NOVEL' named entity 'PROTEIN RECEPTOR' named entity 'ITS' named entity 'HELIX' named entity 'VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1' named entity 'IS A' named entity 'POTENTIAL' named entity 'COMPARED' named entity 'HUMANS' named entity 'ACTIVATE' named entity 'IDENTIFIED' named entity 'PROTEINS' named entity 'LIGAND' named entity 'TCDD' named entity 'NOVEL PROTEIN' named entity 'VALIDATION' named entity 'ONE OF' named entity 'STUDIES' named entity 'IN VITRO' named entity 'DEPENDENT' named entity 'TO IDENTIFY' named entity 'COMPUTATIONAL' named entity 'BIND' named entity 'Results' named entity 'identified' named entity 'TCDD' named entity 'DIOXIN' named entity 'PROTEIN TARGET' named entity 'AFFINITY' named entity 'BASIS' named entity 'MOUSE' named entity 'SIMULATION' named entity 'VEGFR1' named entity 'TARGETS' named entity 'RESULTS' named entity 'SUPERFAMILY' named entity 'ANGIOGENESIS' named entity 'ENVIRONMENTAL CONTAMINANT' named entity 'DEPEND' named entity 'LOOP' named entity 'INTERACTION' named entity 'OVERALL' named entity 'VALIDATION' named entity 'NOVEL PROTEIN' named entity 'IN VITRO' named entity 'PREDICTION' named entity 'TIME' named entity 'PREDICTED' named entity 'USING' named entity 'P-DIOXIN' named entity 'BELONGING' named entity 'HUMAN' named entity 'COMPUTATIONAL' named entity 'VEGFR1' named entity 'TOXIC' named entity 'MOLECULAR DYNAMIC SIMULATION' named entity 'TARGET' named entity 'STABLE' named entity 'ARYL HYDROCARBON RECEPTOR' named entity 'COULD BE' named entity 'STUDY' named entity 'MOLECULAR DOCKING' named entity 'ROLE' named entity 'EXPERIMENTS' named entity 'MANIFESTATIONS' named entity 'PROVIDES' covid:arg/fd0802a5e13561915fb90cbfe5bb12a751197e28 named entity 'TCDD' named entity 'VEGFR1' named entity 'targets'

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