About: Identification of an alternative 5′‐untranslated exon and new polymorphisms of angiotensin‐converting enzyme 2 gene: Lack of association with SARS in the Vietnamese population

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About: Identification of an alternative 5′‐untranslated exon and new polymorphisms of angiotensin‐converting enzyme 2 gene: Lack of association with SARS in the Vietnamese population Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of an alternative 5′‐untranslated exon and new polymorphisms of angiotensin‐converting enzyme 2 gene: Lack of association with SARS in the Vietnamese population
Creator	Hijikata, Minako Keicho, Naoto Matsushita, Ikumi Itoyama, Satoru Kirikae, Teruo Kuratsuji, Tadatoshi Quy, Tran Sasazuki, Takehiko Yanai, Hideki Kirikae, Fumiko Long, Hoang Phi, Nguyen Van Ban, Vo Dang, Le
source	Medline; PMC
abstract	We analyzed genetic variations of angiotensin‐converting enzyme 2 (ACE2), considering that it might influence patients' susceptibility to severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) or development of SARS as a functional receptor. By cloning of the full‐length cDNA of the ACE2 gene in the lung, where replication occurs on SARS‐CoV, it was shown that there are different splicing sites. All exons including the new alternative exon, exon‐intron boundaries, and the corresponding 5′‐flanking region of the gene were investigated and 19 single nucleotide polymorphisms (SNPs) were found. Out of these, 13 SNPs including one non‐synonymous substitution and three 3′‐UTR polymorphisms were newly identified. A case control study involving 44 SARS cases, 16 anti‐SARS‐CoV antibody‐positive contacts, 87 antibody‐negative contacts, and 50 non‐contacts in Vietnam, failed to obtain any evidence that the ACE2 gene polymorphisms are involved in the disease process in the population. Nevertheless, identification of new 5′‐untranslated exon and new SNPs is considered helpful in investigating regulation of ACE2 gene expression in the future. © 2005 Wiley‐Liss, Inc.
has issue date	2005-06-03(xsd:dateTime)
bibo:doi	10.1002/ajmg.a.30779
bibo:pmid	15937940
has license	no-cc
sha1sum (hex)	fd3d54cd54064472333b03513e108d6fbf815ea8
schema:url	https://doi.org/10.1002/ajmg.a.30779
resource representing a document's title	Identification of an alternative 5′‐untranslated exon and new polymorphisms of angiotensin‐converting enzyme 2 gene: Lack of association with SARS in the Vietnamese population
has PubMed Central identifier	PMC7138097
has PubMed identifier	15937940
schema:publication	Am J Med Genet A
resource representing a document's body	covid:fd3d54cd54064472333b03513e108d6fbf815ea8#body_text
is schema:about of	named entity 'development' named entity 'lung' named entity 'case control study' named entity 'polymorphisms' named entity 'replication' named entity 'genetic variations' named entity 'process' named entity 'involved' named entity 'Out' named entity 'gene' named entity 'Vietnam' named entity 'ACE2' named entity 'SARS' named entity 'ACE2' named entity 'polymorphisms' named entity 'intron' named entity 'coronavirus' named entity 'single nucleotide polymorphisms' named entity 'cloning' named entity 'SNPs' named entity 'Polymorphisms' named entity 'SARS' named entity 'Angiotensin-Converting Enzyme 2' named entity 'testis' named entity 'genomic DNA' named entity 'restriction fragment length polymorphism' named entity 'lung' named entity 'non-synonymous' named entity 'receptor' named entity 'Foster City' named entity 'antisense' named entity 'ACE2' named entity 'protein' named entity 'SARS' named entity 'nosocomial infection' named entity 'ACE2' named entity 'chemokine receptor' named entity 'ACE2' named entity 'cloned' named entity 'C-terminal domains' named entity 'exon' named entity 'La Jolla' named entity 'minor allele frequency' named entity 'dbSNP' named entity 'GenBank' named entity 'exon' named entity 'alternative exon' named entity 'asymptomatic' named entity 'testis' named entity 'nonsynonymous' named entity 'coding region' named entity 'primers' named entity 'SARS' named entity 'renin-angiotensin' named entity 'primers' named entity 'antibody' named entity 'exon' named entity 'minor allele frequencies' named entity 'chromosome' named entity 'alternative exon' named entity 'ACE2' named entity 'ACE2' named entity 'SARS' named entity 'serine' named entity 'cDNAs' named entity 'ACE2' named entity 'SARS' named entity 'exon'

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