About: The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia
Creator	Al-Ghamdi, Hadeel Al-Haider, Sami Al-Mogarri, Ibrahim Banjar, Hanaa Chaballout, Mohammad Karkour, Kawthar Nizami, Imran Raja, Rawia Alnakhli, Ali
Source	Elsevier; Medline; PMC
abstract	INTRODUCTION: Studies have shown that pulmonary exacerbations in cystic fibrosis (CF) patients are associated with respiratory viruses. The most common agent causing viral infections in patients with CF before the age of 3 years is respiratory syncytial virus. OBJECTIVES: To obtain the prevalence of the different types of viral infection in CF patients and to identify its relation with the type of bacterial infection, (CFTR) mutations and pulmonary function test (PFT). METHODOLOGY: A retrospective charts review of 387 patients with CF of all age groups who were screened for the detection of viruses during respiratory exacerbation from the period of January 1, 1984 to June 1, 2016. RESULTS: A total of 159 CF patients had pulmonary exacerbation and had viral PCR obtained. Fifty-eight patients (36%) had positive viral PCR. Males were more commonly infected in 30/58 patients (52%) compared to females in 28 patients (48%). Forty-five of 58 patients (78%) were alive and 13 patients (22%) died. Rhinovirus was the most frequently reported viral PCR in 33/74 sample (45%). Out of 74 viral PCR, 41 (55.4%) were during the colder seasons (October–February) and 33 (44.5%) during the warmer seasons (March–September). During viral infection and viral recurrence, there was an increase in bacterial colonization specifically of H. influenza and staphylococcus aureus. The most common CFTR mutation for the CF viral infection is: 3120+1G>A in Intron 16 in 11/57 patients (19%). The Eastern Province had the highest viral infection of 24 out of 57 patients (42%). Follow-up PFT post viral infection showed no significant difference in the type and the severity of PFT compared to the initial PFT during the viral illness. CONCLUSION: Viral infections contributed to the increase in morbidity and mortality of CF patients in our population, and rhinovirus was the most common causative agent. Viral infections and viral recurrence increased the prevalence of bacterial infection of specific pathogens such as H. influenza and S. aureus. Physicians should be aware to prevent progressive lung damage in CF patients by treating the concomitant viral and bacterial infections. Viral infection may be associated with some common CFTR mutations.
has issue date	2019-09-12(xsd:dateTime)
bibo:doi	10.1016/j.ijpam.2019.09.003
bibo:pmid	32292813
has license	no-cc
sha1sum (hex)	fd563a43d4a1a9cbd99d9f45b675a3caeced66a4
schema:url	https://doi.org/10.1016/j.ijpam.2019.09.003
resource representing a document's title	The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia
has PubMed Central identifier	PMC7102630
has PubMed identifier	32292813
schema:publication	Int J Pediatr Adolesc Med
resource representing a document's body	covid:fd563a43d4a1a9cbd99d9f45b675a3caeced66a4#body_text
is schema:about of	named entity 'CYSTIC FIBROSIS' named entity 'CHILDREN' named entity 'PREVALENCE' named entity 'TERTIARY CARE CENTER' named entity 'SAUDI ARABIA' named entity 'VIRAL INFECTIONS' named entity 'PFT' named entity 'CFTR' named entity 'Pseudomonas aeruginosa' named entity 'urogenital' named entity 'morbidity' named entity 'sputum' named entity 'resistance to antibiotics' named entity 'viruses' named entity 'Viral infections' named entity 'RSV' named entity 'lung function' named entity 'viral infection' named entity 'causative agent' named entity 'Staphylococcus' named entity 'sweat glands' named entity 'CFTR' named entity 'rhinovirus' named entity 'nasopharyngeal aspirate' named entity 'H. influenzae' named entity 'Respiratory Syncytial virus' named entity 'dyspnea' named entity 'Eastern region' named entity 'viruses' named entity 'weight loss' named entity 'bacterial culture' named entity 'respiratory symptoms' named entity 'rhinovirus' named entity 'tertiary care' named entity 'genetic mutation' named entity 'viral infections' named entity 'virus infection' named entity 'Middle East Respiratory Syndrome Coronavirus' named entity 'Streptococcus' named entity 'PFT' named entity 'PFT' named entity 'CFTR' named entity 'lung' named entity 'Pulmonary Function Test' named entity 'sample size' named entity 'airway' named entity 'bacterial infections' named entity 'respiratory viral infections' named entity 'PCR' named entity 'pneumonia' named entity 'PFT' named entity 'expectorate' named entity 'S. aureus' named entity 'viral infections' named entity 'rhinovirus' named entity 'gram-negative bacteria' named entity 'MERS-CoV' named entity 'E. coli' named entity 'microbial' named entity 'viruses' named entity 'risk of death' named entity 'pulmonary function' named entity 'bacterial infection' named entity 'pathogens' named entity 'viral infections' named entity 'gene' named entity 'PFT' named entity 'virus' named entity 'virus' named entity 'Staphylococcus aureus' named entity 'lung epithelia' named entity 'PFT' named entity 'viral infections'

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