About: Perniosis during the COVID‐19 pandemic: Negative Anti‐SARS‐CoV‐2 Immunohistochemistry in Six Patients and Comparison to Perniosis Before the Emergence of SARS‐CoV‐2

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About: Perniosis during the COVID‐19 pandemic: Negative Anti‐SARS‐CoV‐2 Immunohistochemistry in Six Patients and Comparison to Perniosis Before the Emergence of SARS‐CoV‐2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Perniosis during the COVID‐19 pandemic: Negative Anti‐SARS‐CoV‐2 Immunohistochemistry in Six Patients and Comparison to Perniosis Before the Emergence of SARS‐CoV‐2
Creator	Harigopal, Malini Bosenberg, Marcus Damsky, William Gehlhausen, Jeff Ko, Christine Mcniff, Jennifer Patrignelli, Robert
Source	Medline; PMC
abstract	BACKGROUND: Acral inflammatory lesions that have some resemblance to idiopathic or autoimmune‐associated perniosis (chilblains) have been described in multiple countries during the COVID‐19 pandemic. METHODS: We examined histopathologic findings in six consecutive such cases from five patients received in mid‐May to mid‐June of 2020, evaluating immunohistochemical staining for the SARS‐CoV‐2 nucleocapsid protein. We compared these six cases to eight cases diagnosed as perniosis between January and June of 2019. RESULTS: Five of six lesions with perniosis‐like histopathology during the COVID‐19 pandemic had distinctive tight cuffing of lymphocytes; intravascular material was present in one case. SARS‐CoV‐2 immunohistochemical staining using an antibody directed at the nucleocapsid protein was negative in all six cases. Only one of eight specimens with microscopic findings of perniosis received prior to the COVID‐19 pandemic had tightly cuffed perivascular lymphocytes, and none had obvious intravascular occlusion. CONCLUSIONS: A tightly cuffed pattern of perivascular lymphocytes is a feature of perniosis during the COVID‐19 pandemic. The absence of SARS‐CoV‐2 nucleocapsid protein in these cases suggests against the virus being directly present in these lesions. This article is protected by copyright. All rights reserved.
has issue date	2020-08-03(xsd:dateTime)
bibo:doi	10.1111/cup.13830
bibo:pmid	32745281
has license	no-cc
sha1sum (hex)	fd6daff76b61c9861a81eeb69212a4b3da049ba5
schema:url	https://doi.org/10.1111/cup.13830
resource representing a document's title	Perniosis during the COVID‐19 pandemic: Negative Anti‐SARS‐CoV‐2 Immunohistochemistry in Six Patients and Comparison to Perniosis Before the Emergence of SARS‐CoV‐2
has PubMed Central identifier	PMC7436569
has PubMed identifier	32745281
schema:publication	J Cutan Pathol
resource representing a document's body	covid:fd6daff76b61c9861a81eeb69212a4b3da049ba5#body_text
is schema:about of	named entity 'directed' named entity 'occlusion' named entity 'pandemic' named entity 'cases' named entity 'Patients' named entity 'Comparison' named entity 'DESCRIBED' named entity 'BEING' named entity 'CONCLUSIONS' named entity 'DIRECTLY' named entity 'SARS-COV-2' named entity 'IDIOPATHIC' named entity 'CASE' named entity 'JANUARY' named entity 'NUCLEOCAPSID PROTEIN' named entity 'ACRAL' named entity 'PRIOR TO' named entity 'MICROSCOPIC FINDINGS' named entity 'MATERIAL' named entity 'COVID-19 PANDEMIC' named entity 'VIRUS' named entity 'ONE OF' named entity 'idiopathic' named entity 'evaluating' named entity 'intravascular' named entity 'Methods' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'nucleocapsid' named entity 'lymphocytes' named entity 'Results' named entity 'lymphocytes' named entity 'protein' named entity 'SARS-CoV-2' named entity 'received' named entity 'Emergence' named entity 'nucleocapsid protein' named entity 'COVID-19 pandemic' named entity 'inflammatory' named entity 'perniosis' named entity 'immunohistochemical staining' named entity 'COVID-19 pandemic' named entity 'intravascular' named entity 'lymphocytes' named entity 'nucleocapsid protein' named entity 'virus' named entity 'Immunohistochemistry' named entity 'SARS-CoV-2' named entity 'antibody' named entity 'histopathology' named entity 'purpuric' named entity 'perniosis' named entity 'perniosis' named entity 'biopsy' named entity 'nucleocapsid' named entity 'chilblain' named entity 'SARS-CoV-2' named entity 'nasopharyngeal swabs' named entity 'immunohistochemical staining' named entity 'SARS-CoV-2' named entity 'immunohistochemical staining' named entity 'Connecticut' named entity 'IgA' named entity 'placental tissue' named entity 'edema' named entity 'infection of the skin' named entity 'Northern hemisphere' named entity 'SARS-CoV-2' named entity 'antiphospholipid antibodies' named entity 'formalin-fixed' named entity 'chilblains' named entity 'perniosis' named entity 'placenta' named entity 'outpatient' named entity 'antibodies'

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