About: Initial Antihypertensive Prescription and Switching: A 5 Year Cohort Study from 250,851 Patients

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About: Initial Antihypertensive Prescription and Switching: A 5 Year Cohort Study from 250,851 Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Initial Antihypertensive Prescription and Switching: A 5 Year Cohort Study from 250,851 Patients
Creator	Cheung, Csk Sek, Ach Tam, Wws Tong, Elh Wong, Mcs
Source	Medline; PMC
abstract	PURPOSE: Adverse effects of antihypertensive therapy incur substantial cost. We evaluated whether any major classes of antihypertensive drugs were significantly associated with switching as a proxy measure of medication side effects in a large Chinese population in Hong Kong. METHODS: From a clinical database, all adult patients newly prescribed an antihypertensive mono-therapy in Hong Kong between the years 2001–2003 and 2005 were included. Those who paid only one visit, died or stayed in the cohort for <180 days after the prescription, or prescribed more than one antihypertensive agent were excluded. The factors associated with switching at 180 days were evaluated by multivariate regression analyses. Age, gender, payment status, service type, district of residence, drug class, systolic and diastolic blood pressure levels were predictor variables. RESULTS: From 250,851 subjects, 159,813 patients were eligible. A total of 6,163 (3.9%) switched their medications within 180 days. Patients prescribed thiazide diuretics had the highest switching rate (5.6%), followed by ACEIs (4.5%), CCBs (4.4%) and beta-blockers (3.2%). When compared with ACEIs, patients on thiazide diuretics were significantly more likely to be switchers (adjusted odds ratio [AOR] 1.49, 95% C.I. 1.31–1.69, p<0.001), whilst patients prescribed CCBs and beta-blockers were similarly likely to have switching. Following these patients up for 5 years showed that thiazide had the most marked increase in switching rate. CONCLUSIONS: The higher rates of switching among thiazide diuretics in this study might raise a probably greater incidence of their adverse effects in this Chinese population, yet other factors might also influence switching rates. Patients prescribed thiazide diuretics for longer term should be observed for their intolerability.
has issue date	2013-01-14(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0053625
bibo:pmid	23341959
has license	cc-by
sha1sum (hex)	fdd06eeb020a963754fee36852a5918a93f7856d
schema:url	https://doi.org/10.1371/journal.pone.0053625
resource representing a document's title	Initial Antihypertensive Prescription and Switching: A 5 Year Cohort Study from 250,851 Patients
has PubMed Central identifier	PMC3544913
has PubMed identifier	23341959
schema:publication	PLoS One
resource representing a document's body	covid:fdd06eeb020a963754fee36852a5918a93f7856d#body_text
is schema:about of	named entity 'Prescription' named entity 'EVALUATED' named entity 'ANTIHYPERTENSIVE THERAPY' named entity 'MEDICATION SIDE EFFECTS' named entity 'LARGE' named entity 'PROXY' named entity 'ADVERSE EFFECTS' named entity 'CHINESE' named entity 'ASSOCIATED WITH' named entity 'HONG KONG' named entity 'ANTIHYPERTENSIVE DRUGS' covid:arg/fdd06eeb020a963754fee36852a5918a93f7856d named entity 'MAJOR' named entity 'COHORT STUDY' named entity 'PATIENTS' named entity 'SWITCHING' named entity 'PRESCRIPTION' named entity '250' named entity 'YEAR' named entity 'INITIAL' named entity 'ANTIHYPERTENSIVE' named entity 'PURPOSE' named entity 'COST' named entity 'SWITCHING' named entity 'CLASSES' named entity 'MEASURE' named entity 'POPULATION' named entity 'therapy' named entity 'cost' named entity 'substantial' named entity 'Purpose' named entity 'antihypertensive therapy' named entity 'Hong Kong' named entity 'antihypertensive' named entity 'arterial hypertension' named entity 'thiazide diuretics' named entity 'diastolic blood pressure' named entity 'medical condition' named entity 'blood pressure' named entity 'Combination therapy' named entity 'diastolic blood pressure' named entity 'primary care' named entity 'comorbidities' named entity 'pharmacoepidemiological' named entity 'epidemic' named entity 'Hong Kong' named entity 'Demographic' named entity 'outcome variable' named entity 'DBP' named entity 'out-patient' named entity 'drug therapy' named entity 'SBP' named entity 'cardiovascular' named entity 'antihypertensive drugs' named entity 'in-patient' named entity 'drug prescription' named entity 'primary care clinics' named entity 'out-patient' named entity 'stroke' named entity 'Hospital Authority' named entity 'antihypertensive agents' named entity 'beta-blockers' named entity 'unique identifier' named entity 'potassium' named entity 'dyslipidemia' named entity 'Hong Kong' named entity 'systolic' named entity 'antihypertensive agent' named entity 'antihypertensive drug' named entity 'blood pressure' named entity 'diabetes' named entity 'first-line' named entity 'public assistance' named entity 'hypertension' named entity 'antihypertensive drug' named entity 'Western' named entity 'predictor variables'

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